Licochalcone D exhibits cytotoxicity in breast cancer cells and enhances tumor necrosis factor‐related apoptosis‐inducing ligand‐induced apoptosis through upregulation of death receptor 5
Yunyun Zhang,
Linlin Wang,
Chuxuan Dong
et al.
Abstract:Anticancer strategies using natural products or derivatives are promising alternatives for cancer treatment. Here, we showed that licochalcone D (LCD), a natural flavonoid extracted from Glycyrrhiza uralensis Fisch, suppressed the growth of breast cancer cells, and was less toxic to MCF‐10A normal breast cells. LCD‐induced DNA damage, cell cycle arrest, and apoptosis in breast cancer cells. Furthermore, LCD potentiated tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐induced cytotoxicity. Mechan… Show more
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