Lichenoid drug eruption secondary to treatment with nicorandil?

Majmudar, V.; Al-Dulaimi, H; Dodd, Harold

doi:10.1111/j.1365-2230.2007.02646.x

Cited by 14 publications

(8 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In idiopathic lichen planus, flat-topped, shiny, violaceous papules with Wickham's striae and a predilection for the wrists, flexures, genitalia and mucous membranes are seen. It has been described that drug-induced lichen planus may appear psoriasiform or eczematous, rarely involves the mucosae and affects older patients and photoexposed areas [1, 3]. Histopathologic findings including the presence of plasma cells, neutrophils and eosinophils in the cellular infiltrate, focal eosinophils with a thin epidermis and hypogranulosis, and a superficial and deep perivascular infiltrate are features associated more commonly with drug-induced lichen planus [1, 4].…”

Section: Discussionmentioning

confidence: 99%

Lichenoid Drug Eruptionfollowing Intravenous Applicationof Orally Formulated Diamorphine, a Semisynthetic Heroin

et al. 2013

View full text Add to dashboard Cite

Background: Lichen planus is a common skin disorder of unknown etiology. Most cases are idiopathic, but substances such as gold, antimalarials, penicillamine, thiazide diuretics, β-blockers, arsenic and nonsteroidal anti-inflammatory drugs have been implicated as trigger factors. Case Presentation: We report the case of a lichenoid eruption in a male drug addict who administered oral heroin (diamorphine) intravenously. Diamorphine was stopped immediately. Following topical steroids, phototherapy and oral acitretin, the lesions gradually disappeared. A lymphocyte transformation test was negative for pure morphine and codeine. Discussion: A coincidental association between the intravenous application of orally formulated semisynthetic heroin and the lichenoid eruption cannot be completely ruled out. However, the diagnosis of a lichenoid drug eruption is favoured over idiopathic lichen planus because of the clear chronological correlation between drug use and appearance as well as drug withdrawal and disappearance of the skin lesions, and because of a flare-up following repeated intravenous application of diamorphine.

show abstract

Section: Discussionmentioning

confidence: 99%

Lichenoid Drug Eruptionfollowing Intravenous Applicationof Orally Formulated Diamorphine, a Semisynthetic Heroin

et al. 2013

View full text Add to dashboard Cite

show abstract

“…This 10‐year survey of 148 French cases of NIU is the first available survey based on spontaneous pharmacovigilance reports of both cutaneous and mucosal lesions induced by nicorandil. During this same period, 199 other cases were reported worldwide in 61 published articles: 173 cases of mucosal lesions, 21 cases of cutaneous lesions and 5 cases of mucosal and cutaneous lesions (Table ) .…”

Section: Discussionmentioning

confidence: 98%

Nicorandil‐induced ulcerations: a 10‐year observational study of all cases spontaneously reported to the French pharmacovigilance network

Babic

Petitpain²,

Guy

et al. 2018

International Wound Journal

View full text Add to dashboard Cite

Nicorandil-induced ulcers remain often poorly recognised, with a late diagnosis and an inadequate management. We aimed to provide a clinical overview of the 148 spontaneously reported cases of nicorandil-induced ulcers to the French pharmacovigilance network between 2005 and 2014 and to complete this picture with worldwide published cases over the same period. Spontaneously reported nicorandil-induced ulcers were mainly mucosal (oral and anal) with a previous trauma in 23·0% of patients, revealed by a severe complication in 12·8% of cases. The mean cumulative dose of nicorandil was higher in serious cases. The median delay between the start of nicorandil use and the onset of the ulcer was 23·4 months, and after the ulcer was diagnosed, the median time to incriminate nicorandil was still 3·3 months, being shorter for mucosal ulcerations than for cutaneous ulcerations (5·2 versus 14·0 months, P = 0·001). The anatomic distribution in the 199 published cases differed slightly, but delays were similar. The hypothesis of mechanism becomes more precise, leaving no doubt about the necessity to discontinue the treatment. Practitioners need to be aware that nicorandil-induced ulcers can occur in many locations, possibly multiple and complicated, and should be simply managed by discontinuing treatment with no further reintroduction of nicorandil.

show abstract

“…After stopping the drug, the altered keratinocytes are cleared and that leads to resolution of the rash. [ 2 ]…”

Section: Discussionmentioning

confidence: 99%

Blaschkoid lichenoid drug eruption due to tenofovir

Virath

Balai

Gupta

2020

Indian Dermatol Online J

View full text Add to dashboard Cite

Lichenoid drug eruption secondary to treatment with nicorandil?

Cited by 14 publications

References 3 publications

Lichenoid Drug Eruptionfollowing Intravenous Applicationof Orally Formulated Diamorphine, a Semisynthetic Heroin

Lichenoid Drug Eruptionfollowing Intravenous Applicationof Orally Formulated Diamorphine, a Semisynthetic Heroin

Nicorandil‐induced ulcerations: a 10‐year observational study of all cases spontaneously reported to the French pharmacovigilance network

Blaschkoid lichenoid drug eruption due to tenofovir

Contact Info

Product

Resources

About