Lichen sclerosus is frequently present in penile squamous cell carcinomas but is not always associated with oncogenic human papillomavirus

Abstract

Penile SCC seems to be frequently associated with LS histological changes. As with vulval SCC, we found that non-LS-associated penile SCC tended to be frequently associated with oncogenic HPV infection, whereas LS-associated penile SCC was not. Larger series are needed to confirm this association.

Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients

“…However, as in the vulvar lesions, this issue remains controversial since some studies support the association between lichen sclerosus and differentiated variants of intraepithelial lesions [22][23][24][25][26], yet others do not [27,28]. In our experience, warty or basaloid PeIN is occasionally encountered in a background of lichen sclerosus.…”

“…In our experience, warty or basaloid PeIN is occasionally encountered in a background of lichen sclerosus. Notwithstanding these seemly contradictory data, there are bona fide reports of carcinomas arising in a background of lichen sclerosus [22,24,25], highlighting the The preferential anatomical location of differentiated PeIN was in the foreskin, whereas those with poorly differentiated warty and/or basaloid features predominated in the glans. It may be that, as in the cervix and anal canal, HPV-related tumors tend to originate in a transitional epithelium, in this case, the urethra-penile epithelia.…”

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

“…They are most common on the glans over the shaft, prepuce and groin, and can also be seen around the anus. Lack of circumcision, HPV, 150 infection and genital lichen sclerosus [151][152][153][154] are important risk factors in all forms of PIN. 147,155 Circumcision is therefore an essential component of the management of most cases of PIN.…”

Identification and genotyping of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: Correlation with pathologic subtypes, p16INK4a expression, and prognosis

“…[3][4][5] There are limited data about the role of HPV in PSCC, and only a few studies on small series of patients from the Mediterranean area have focused in this topic. [6][7][8][9] HPV genotypes are currently classified according to their oncogenic potential in lowand high-risk subtypes, being the high-risk genotypes those usually found in premalignant and malignant lesions from the mucosal areas. 10 Depending on the detection method, geographic area, and tumor type, the infection rates of HPV in PSCC range from 20% to 80%.…”