Lichen Sclerosus et Atrophicus of the Vulva

Suurmond, D.

doi:10.1001/archderm.1964.01600020011002

Cited by 34 publications

(8 citation statements)

References 20 publications

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“…Another factor is the likelihood of a large pool of undiagnosed lichen sclerosus in the community. Further evidence supporting a temporal sequence between lichen sclerosus and cancer is that the mean age of diagnosis of lichen sclerosus is 54-56 years and that of HPV-negative squamous cell carcinoma 73, giving a lead time of 17-19 years (12,(33)(34)(35)(36) .…”

Section: Temporal Relationship Between Lichen Sclerosus and Sccmentioning

confidence: 99%

Does lichen sclerosus play a central role in the pathogenesis of human papillomavirus negative vulvar squamous cell carcinoma? The itch-scratch-lichen sclerosus hypothesis

Scurry¹

1999

Int J Gynecol Cancer

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In the past decade, two types of vulvar squamous cell carcinoma (SCC) have been delineated, Human papillomavirus (HPV) positive and negative. Clinicopathologic, virologic, cytomorphometric, and genetic differences support the view that these two types of carcinoma are fundamentally different and that HPV‐negative carcinoma is not simply carcinoma where viral DNA has not been able to be identified. The traditional view of HPV‐negative carcinoma is that it is caused by chronic tissue damage from itching and scratching. However, itching and scratching alone do not explain the close association of carcinoma with lichen sclerosus, nor the absence of such an association with other itchy conditions such as eczema or psoriasis. These observations point to a role for lichen sclerosus in the pathogenesis of vulvar carcinoma. Most observations about the etiology of lichen sclerosus can be grouped into its immunogenetic or genital predisposition, or the Köbner phenomenon. In the itch‐scratch‐lichen sclerosus hypothesis, lichen sclerosus is postulated to occur as a Köbner phenomenon in women with the susceptible immunophenotype who scratch because of genital irritants such as urine, vaginal secretions and smegma, and psychological factors. Lichen sclerosus, itself a very itchy condition, contributes to a vicious cycle of itching and scratching which leads to superimposed lichen simplex chronicus, squamous cell hyperplasia, and ultimately carcinoma. The itch‐scratch‐lichen sclerosus hypothesis reconciles the traditional itch‐scratch hypothesis with the strong clinicopathologic association of lichen sclerosus with carcinoma.

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Section: Temporal Relationship Between Lichen Sclerosus and Sccmentioning

confidence: 99%

Does lichen sclerosus play a central role in the pathogenesis of human papillomavirus negative vulvar squamous cell carcinoma? The itch-scratch-lichen sclerosus hypothesis

Scurry¹

1999

Int J Gynecol Cancer

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“…33,34 Further studies in the 1960s highlighted the importance of vulval lichen sclerosus. 35,36 The name lichen sclerosus et atrophicus was widely used in the dermatological and the gynecological literature but arguments against the atrophic nature of the disease resulted in the term``lichen sclerosus'' being formally adopted by the ISSVD in 1976. 37 The association of lichen sclerosus and malignancy was ®rst discussed in the early 20th century.…”

Section: Lichen Sclerosusmentioning

confidence: 99%

Vulval Disease from the 1800s to the New Millennium

Lewis

2002

Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology

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“…[4,14,15,21]. L'observation prolongée d'un nombre im portant de nos m a lades, nous a permis de pouvoir suivre chez elles toutes les phases intermédiaires conduisant l'image du L.S.A.V.…”

Section: Il Quelle Est La Place Qu'on Doit Réserver Au L Sa V Paunclassified

“…Sur la localisation vulvaire du lichen srléro-a trophique vulvaire du L.S.A. ne ferait donc pas partie de l'évolution naturelle de cette affection, mais elle traduirait, ainsi que l'observation de nos cas nous l'a m ontré, l'intervention d'un autre processus pathologique, qui se superpose fréquem ment à elle, à savoir le développement à la sur face de la lésion propre du L.S.A.V., de plaques leucoplasiques, lésions à potentiel oncogène, comme l'on sait, très prononcé [17,21,22,23,24].…”

Section: Le L Sa V ' Est-il Capable De Subir Dans Certaines Circounclassified

Sur la localisation vulvaire du lichen scléro-atrophique

Nicolau¹,

Băluş²

1966

Dermatology

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Lichen Sclerosus et Atrophicus of the Vulva

Cited by 34 publications

References 20 publications

Does lichen sclerosus play a central role in the pathogenesis of human papillomavirus negative vulvar squamous cell carcinoma? The itch-scratch-lichen sclerosus hypothesis

Does lichen sclerosus play a central role in the pathogenesis of human papillomavirus negative vulvar squamous cell carcinoma? The itch-scratch-lichen sclerosus hypothesis

Vulval Disease from the 1800s to the New Millennium

Sur la localisation vulvaire du lichen scléro-atrophique

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