Lichen planus: review and update on pathogenesis

Scully, Crispian; El-Kom, M.

doi:10.1111/j.1600-0714.1985.tb00516.x

Cited by 348 publications

(233 citation statements)

References 270 publications

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“…Lichen planus is thought to reflect a cell-mediated reaction, with T lymphocytes as the main effector cells. 35 A few cases of OLP have been associated with diabetes mellitus 36 and candidiasis. 37 Under the microscope the affected area shows characteristic change: a band-like, mainly lymphocytic, immuno-inflammatory infiltration next to the basement membrane.…”

Section: Discussionmentioning

confidence: 99%

Oral lichenoid lesions related to dental restorative materials

Issa

Duxbury²,

Brunton³

2005

Br Dent J

105

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Section: Discussionmentioning

confidence: 99%

Oral lichenoid lesions related to dental restorative materials

Issa

Duxbury²,

Brunton³

2005

Br Dent J

105

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“…O ral lichen planus (OLP) is one of the most common oral mucosa diseases, occurring in approximately 1% of the general population (Pindborg et al, 1972;Scully and el-Kom, 1985). Unlike cutaneous lichen planus, OLP tends to be chronic.…”

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confidence: 99%

High Frequency of Allelic Loss in Dysplastic Lichenoid Lesions

Zhang

Cheng

et al. 2000

Laboratory Investigation

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SUMMARY:Oral lichen planus (OLP) is a common mucosal condition that is considered premalignant by some, whereas others argue that only lichenoid lesions with epithelial dysplasia are at risk of progressing into oral carcinoma. A recent study from this laboratory used microsatellite analysis to evaluate OLP for loss of heterozygosity (LOH) at loci on three chromosomal arms (3p, 9p, and 17p) (Am J Path 1997;Vol151:Page323-Page327). Loss on these arms is a common event in oral epithelial dysplasia and has been associated with risk of progression of oral leukoplakia to cancer. The data showed that, although dysplastic epithelium demonstrated a high frequency of LOH (40% for mild dysplasia), a significantly lower frequency of LOH was noted in OLP (6%), which is even lower than that in hyperplasia (14%). Such results do not support OLP as a lesion at risk for malignant transformation. As a second step of the research, we determined LOH frequencies in 61 dysplastic lichenoid lesions (mild 35; moderate 19; severe 7) using the same microsatellite markers and compared these results with data obtained from the first study and from 13 normal mucosal specimens. Dysplastic lichenoid lesions showed a high frequency of loss (54% for lichenoid lesions with mild dysplasia), but values did not differ significantly from those observed in dysplasia of similar degree without lichenoid appearance. None of the normal mucosa demonstrated LOH. Epithelial dysplasia is a sign of malignant risk, independent of lichenoid changes. Such results suggest that pathologists should search for dysplasia carefully in lesions that otherwise qualify as OLP and that caution should be used when discounting dysplasia as being merely a reactive condition in lichenoid lesions. (Lab Invest 2000, 80:233-237).

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“…[6] Though this condition was considered rare in children in older days, it is now being frequently reported in recent literature. Sharma et al, 1991 reported 50 children with LP, out of which 15 children were noticed with concomitant oral lesions.…”

Section: Discussionmentioning

confidence: 99%

Juvenile oral erosive lichen planus - A rare case report

Jahan¹,

Vandana²,

Rangdhol³

et al. 2017

IJMDCR

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Lichen planus (LP) is a chronic autoimmune mucocutaneous disease that predominantly affects adults and occurs less frequently in the pediatric patients. Oral LP in childhood is a rare entity with very few cases cited in the literature. The objective of this paper is to contribute a clinically and histologically documented case of juvenile oral LP to the literature. Despite the fact of rare occurrence, early identification and diagnosis of this condition by dental specialists can have a huge impact on the oral health of affected pediatric patients.

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Lichen planus: review and update on pathogenesis

Cited by 348 publications

References 270 publications

Oral lichenoid lesions related to dental restorative materials

Oral lichenoid lesions related to dental restorative materials

High Frequency of Allelic Loss in Dysplastic Lichenoid Lesions

Juvenile oral erosive lichen planus - A rare case report

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