Lichen planus occurring after hepatitis B vaccination: A new case

Al-Khenaizan, Sultan

doi:10.1067/mjd.2001.114590

Cited by 39 publications

(37 citation statements)

References 8 publications

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“…In our case the failure of systemic corticosteroid treatment to resolve the LP lesions led us to initiate metronidazole therapy, as suggested by Büyük & Kavala 16 . Many authors do not recommend continuing with the HBV vaccination after the appearance of LP secondary to the vaccination 1 …”

Section: Discussionmentioning

confidence: 78%

“…The medical community has accepted as safe the vaccine for HBV, a purified, genetically engineered single antigen 4 . However, reports of immunological reactions after HBV vaccination have emerged in general medicine (myelitis, neuritis, vasculitis and multiple sclerosis) 4 and in dermatology literature (lichen planus 1,3,5–10 lichenoid reactions 11,12 granuloma annulare 2 or necrobiotic granuloma 13 ). We should not forget that this vaccination still has a very favourable benefit/risk ratio, as each year all over the world there are two million deaths caused by cirrhosis or primary liver cancer in 250 million of chronic carriers of HBV 2…”

Section: Discussionmentioning

confidence: 99%

“…Lichen planus (LP) is a pruritic idiopathic inflammatory dermatosis of unknown origin 1 . An association between viral infection and LP was postulated long ago, but only recently have HBV and hepatits C virus (HCV) been incriminated 3 .…”

Section: Discussionmentioning

confidence: 99%

“…It therefore seems likely that the immune system recognizes an epitope on keratinocytes that is similar or identical to protein S of the virus and thus stimulates cytotoxic T lymphocytes to induce apoptosis of disturbed keratinocytes 14 . T lymphocytes probably have the main role in the maintenance of this inflammatory reaction 1 . Other substances in the vaccine, e.g.…”

Section: Discussionmentioning

confidence: 99%

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Two case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulare

Criado¹,

Ramos²,

Vasconcellos³

et al. 2004

Acad Dermatol Venereol

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We report two cases of adverse cutaneous reactions following hepatitis B vaccination. The first case occurred 3 weeks after the first dose of hepatitis B vaccine in a 16-year-old white girl with the onset of lichen planus lesions on her thighs and abdomen. After the second dose a disseminated lichen planus developed within 2 weeks. The second case concerns to the development of papular and patch granuloma annulare in a 58-year-old white woman 2 months after the second dose of hepatitis B vaccine. To the best of our knowledge, only a few paediatric and adult cases of lichen planus as a complication of hepatitis B vaccination have been reported in medical literature so far. This is the second case of granuloma annulare following hepatitis B vaccine. Our report, similar to earlier papers, appears to support the onset of lichen planus and granuloma annulare as a possible rare complication of hepatitis B immunization.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Two case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulare

Criado¹,

Ramos²,

Vasconcellos³

et al. 2004

Acad Dermatol Venereol

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“…But, it has been suggested that there is a cross‐reactivity between the HBsAg used in HBV vaccines and shared epitopes on keratinocytes. The developing of lichen planus subsequent to passive immunization with human anti‐HBV immunoglobulins may support this hypothesis (15).…”

Section: Linear Lichen Striatus On the Abdomen The Characteristic S‐mentioning

confidence: 97%