Lichen Planus-like Lesions Caused by Penicillamine in Primary Biliary Cirrhosis

Seehafer, James R.; Rogers, Roy S.; Fleming, C. Richard; Dickson, E. Rolland

doi:10.1001/archderm.1981.01650030018010

Cited by 64 publications

(9 citation statements)

References 15 publications

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“…FFA has been previously associated with other immune-mediated disorders, such as lupus erythematosus, Hashimoto's thyroiditis, and rheumatoid arthritis [3,4]. Additionally, the coexistence of PBC in patients with lichen planus and oral lichen planus has been described in the literature [10,11,12]. Koulentaki et al [13] reported that the incidence rates of cutaneous lichen planus and oral lichen planus in patients with PBC were 10.2% (5/29 cases) and 8.2% (4/49), respectively.…”

Section: Discussionmentioning

confidence: 99%

A Case of Frontal Fibrosing Alopecia in a Patient with Primary Biliary Cirrhosis and Polymyalgia Rheumatica

Eginli

Bagayoko

McMichael

2016

Skin Appendage Disord

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Frontal fibrosing alopecia (FFA) is a form of scarring hair loss that is characterized by hair follicle destruction in a fronto-temporo-parietal distribution. Its etiology is unknown; however, most authors presently favor an immune pathogenesis. Associated autoimmune connective tissue diseases have been reported in patients with FFA. We present a case of FFA in a woman with primary biliary cirrhosis and polymyalgia rheumatica, suggesting an association between these clinical entities and supporting a potential autoimmune etiology of FFA.

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Section: Discussionmentioning

confidence: 99%

A Case of Frontal Fibrosing Alopecia in a Patient with Primary Biliary Cirrhosis and Polymyalgia Rheumatica

Eginli

Bagayoko

McMichael

2016

Skin Appendage Disord

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“…The cutaneous side effects of captopril are remarkably similar to those of D-penicillamine, e.g. pemphigus [9,10] or lichenoid eruption [11]. Each compound has a sulfhydryl group, probably responsible for these similar adverse cutaneous reactions.…”

Section: Introductionmentioning

confidence: 91%

Captopril-Induced Lichen planus pemphigoides with Pemphigus-Like Features

et al. 1986

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We report a case of a bullous lichenoid eruption due to the intake of captopril. Clinical, histological, direct immunofluorescence and ultrastructural features were consistent with the diagnosis of lichen planus pemphigoides. In addition, the in vivo immunological study also revealed an intercellular fluorescence, similar to that seen in pemphigus. Complex drug-induced cutaneous reactions have been previously reported with other drugs, especially with D-penicillamine, which bears chemical similarities with captopril. However, such a drug-induced mixed pattern of lichen planus pemphigoides with pemphigus-like features has never been reported.

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“…The liver diseases that seem to be most strongly related to OLP are chronic liver diseases, especially chronic active hepatitis (CLD) and primary biliary cirrhosis (PBC). Most cases of oral lichenoid lesions in PBC have been associated with penicillamine treatment (Powell and Rogers, 1981;Seehafer et al, 1981;Powell et al, 1982), but some have not (Graham-Brown et al, 1982;Powell et al, 1982;Oleaga et cil., 1995). Chronic active hepatitis, however, is the chronic liver disease (CLD) that does seem to be associated with LP in certain circumstances.…”

Section: (3) Drugsmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

471

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Lichen Planus-like Lesions Caused by Penicillamine in Primary Biliary Cirrhosis

Cited by 64 publications

References 15 publications

A Case of Frontal Fibrosing Alopecia in a Patient with Primary Biliary Cirrhosis and Polymyalgia Rheumatica

A Case of Frontal Fibrosing Alopecia in a Patient with Primary Biliary Cirrhosis and Polymyalgia Rheumatica

Captopril-Induced Lichen planus pemphigoides with Pemphigus-Like Features

Update On Oral Lichen Planus: Etiopathogenesis and Management

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