Lichen planus, lichenoid drug reactions, and lichenoid mucositis

DeRossi, Scott S.; Ciarrocca, Katharine

doi:10.1016/j.cden.2004.08.004

Cited by 72 publications

(113 citation statements)

References 39 publications

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“…3 The name "lichen planus" was provided by the British physician Erasmus Wilson, who first described the condition in 1869. Oral lichen planus (OLP), is a common chronic inflammatory mucocutaneous disease affecting middle aged women with a prevalence rate of 1% to 2% worldwide, 4 but in India it varies from 0.1% to 1.5%. 5 The annual malignant transformation rate of OLP varies 0.04% and 1.74%.…”

Section: Introductionmentioning

confidence: 99%

“…5 The annual malignant transformation rate of OLP varies 0.04% and 1.74%. 4 Photodynamic therapy (PDT) is an effective treatment modality of OLP, OL and initial stages of head and neck cancer. 6 The synonyms of PDT are photoradiation therapy, phototherapy, or photochemotherapy, which uses a photosensitizer (photoactive dye), activated by light of a specific wavelength in the presence of oxygen.…”

Section: Introductionmentioning

confidence: 99%

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Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

et al. 2016

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Introduction: Oral premalignant lesions are conditions having high potential tendency for transformation into malignancy. The use of a conservative and effective treatment modality is one of the best strategies for cancer prevention. Photodynamic therapy (PDT) is a noninvasive method for topical and selective treatment of oral precancerous lesions. The present study was taken up to determine the efficacy of PDT in oral precancerous lesions. Methods: The study consisted 13 patients with 24 oral leukoplakia (OL) lesions and 8 with 20 oral lichen planus (OLP) lesions, divided into control and study groups. These lesions were affecting various intraoral sites, the buccal mucosa being the most common site followed by tongue and gingiva. The treatment regimen of PDT included 98% 5-aminolevulinic acid (5-ALA) which is topical applied and irradiated with light emitting diode (LED) of 420 nm wavelengths at several sessions. Results: In OL 16.6% of cases showed complete response, 66.6% partial response and 16.6% no response of the lesions to the treatment. In OLP 80% and 20% of the lesions showed partial and no response respectively. The differences with control groups for OL + OLP were found to be significant (P < 0.001). Conclusion: Based on the results of the present study, we can conclude that PDT appears to be a feasible alternative to conventional therapy for oral premalignant lesions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

et al. 2016

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“…The resolution of symptoms may be immediate or may take several months, in which case treatment of the OLDR with topical corticosteroids in addition to the reduction in dose or discontinuation of the offending agent may be required [1,2]. The ultimate proof of diagnosis is recurrence on rechallenge, but this is not always possible or desirable.…”

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confidence: 99%

Lichenoid Mucosal Reaction to Rituximab

2014

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“…Any sign of non-traumatic ulceration in the oral mucosa associated with typical lichen signs indicated erosive OLP (EOLP). 22 The participants underwent evaluations of for TPOAb level using IMMULITE 2000 anti-TPO (EURO/DPC; United Kingdom). IL-8 levels were measured using an Interleukin-8 Elisa kit (Bender MedSystems; Austria).…”

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confidence: 99%

Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients

et al. 2017

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This study considered a possible relationship between the severity of oral lichen planus (OLP), serum anti-TPO autoantibodies (TPOAb) titer and thyroid disease in OLP patients. Forty-six OLP patients with positive TPOAb results (> 35 IU/ml) who had also been diagnosed with thyroid disease were included in the study group. The control group consisted of 46OLP patients with no thyroid disease. The study and control groups (92) were divided to two subgroups of erosive OLP (EOLP) and non-erosive OLP (NEOLP). Serum TPOAb levels and IL-8 (to measure OLP severity) were evaluated using the independent t-test, chi-square and conditional logistic regression analysis (α = 0.05). A significant positive correlation was found between serum IL-8 and TPOAb levels in the study group (r = 0.783; p = 0.001). The positive blood levels of TPOAb were significantly associated with an increased risk of EOLP (OR = 4.02 at 95%CI; 1.21-13.4; p = 0.023). It is possible to used positive serum TPOAb levels in patients with OLP as in indicator of possible undetected thyroid disorders in those patients. Because erosive OLP has been associated with TPOAb in thyroid patients, it may be useful to determine TPOAb levels of such patients to diagnose a possible undetected thyroid disorders and follow-up for malignancy.

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Lichen planus, lichenoid drug reactions, and lichenoid mucositis

Cited by 72 publications

References 39 publications

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

Lichenoid Mucosal Reaction to Rituximab

Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients

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