Lichen Planus in Association with Adult-onset Still’s Disease Successfully Treated with Mycophenolate Mofetil

Emad, Yasser; Ragab, Yasser; El-Shaarawy, Nashwa

doi:10.3899/jrheum.120032

Cited by 10 publications

(8 citation statements)

References 12 publications

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“…Although this relatively well‐tolerated immunosuppressive agent has shown promise for some skin conditions such as psoriasis, pemphigus vulgaris, pyoderma gangrenosum, lupus erythematosus and dermatomyositis, weak evidence thus far exists supporting its use in LP. However, case reports involving mucocutaneous LP, disseminated hypertrophic LP or bullous LP have been published.…”

Section: Mycophenolate Mofetilmentioning

confidence: 99%

Lichen planus: a comprehensive evidence‐based analysis of medical treatment

Husein‐ElAhmed

Gieler

Steinhoff

2019

Acad Dermatol Venereol

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Lichen planus (LP) is a chronic-relapsing inflammatory skin disease. Although many drugs have been used for the management of LP, some of them lack the backup by strong therapeutic evidence, while others are not suitable for some patients due to safety profile issues. The aim of this study was to review the recent status of available medical therapies for LP to help physicians make better decisions upon best medical practice while facing patients with this condition. A review of published articles on management of LP was conducted with the MEDLINE and PubMed databases. The quality of the evidence was graded as high, moderate, low or very low. A total of 1366 articles were retrieved, and 219 (16%) were included in the final analysis. Twenty-one different treatment modalities were analysed. The quality of evidence was high for topical steroid and calcineurin inhibitor, while it was moderate for oral steroids. All the other modalities reached low or very low quality of evidence. Topical steroids and calcineurin inhibitors are the current first-line therapies, while for other therapies the strength of recommendation is not so evident. Unfortunately, larger randomized, controlled trials to support the efficacy, safety and tolerability of other therapies in LP are lacking, and many of them are recommended based on studies with small sample sizes, lack of standardized outcome measures or lack of controlled duration or even in anecdotal evidence. Thus, large-scale randomized clinical trials are still warranted to establish the exact benefits of other topical treatments, phototherapy, immunosuppressant and new immunomodulators for an optimized treatment of LP.

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Section: Mycophenolate Mofetilmentioning

confidence: 99%

Lichen planus: a comprehensive evidence‐based analysis of medical treatment

Husein‐ElAhmed

Gieler

Steinhoff

2019

Acad Dermatol Venereol

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“…12,13 In addition to empiric management, starting tacrolimus was planned if any flare-up of the disease occurred during the follow-up because there have been studies suggesting the role of tacrolimus in refractory Still's disease. 14,15 Subsequent follow-up in the ambulatory outpatient clinic setting was uneventful, hence tacrolimus was not used in the patient.…”

Section: Case Presentationmentioning

confidence: 99%

Interstitial Lung Disease: A Rare Association with Adult-Onset Still’s Disease

Asghar¹,

Fatmi²,

Zafar³

et al. 2020

EMJ Respir

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Pulmonary lung involvement in adult-onset Still’s disease (AOSD) can be classified into two categories: with or without acute respiratory distress syndrome. Interstitial fibrosis in AOSD is rare, occurring in less than 5% of cases. Here, the authors present a case of a 40-year-old male of Asian descent with a past history of hyperthyroidism who presented with fever, shortness of breath associated with cough, sore throat, diffuse arthralgias, pink-coloured rash, and hepatomegaly. Laboratory investigations revealed leukocytosis, abnormal liver function tests, negative antinuclear antibodies, and negative rheumatoid factor. Chest X-ray showed bilateral basal infiltrates, while high-resolution CT chest scan confirmed the diagnosis of interstitial lung disease in association with ASOD. This case suggested a direct association of AOSD and interstitial lung disease, but autoimmune pathogenesis is the only link synchronising both diseases and the exact mechanism of direct involvement is ambiguous.

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“…Familial cases are uncommon, and rarely these are associated with HLA-D7. An association with HLA-DR1 has been found in nonfamilial cases ( Figure 5) [9][10][11][12][13][14].…”

Section: Lichen Planusmentioning

confidence: 99%

Common Skin Lesions of the Face

Azizi¹,

Zarinpour²,

Hasrak³

2016

A Textbook of Advanced Oral and Maxillofacial Surgery Volume 3

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Skin lesions are common and range from acute inflammatory dermatoses, such as urticaria, to malignant melanoma, which may be life-threatening. When confronting skin diseases, it is important that the maxillofacial surgeon collaborate with both the dermatologist and pathologist. The clinical history, gross appearance, and course of any disease are as important as the microscopic findings. In this chapter, we discuss the more common skin lesions of the face.

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Lichen Planus in Association with Adult-onset Still’s Disease Successfully Treated with Mycophenolate Mofetil

Cited by 10 publications

References 12 publications

Lichen planus: a comprehensive evidence‐based analysis of medical treatment

Lichen planus: a comprehensive evidence‐based analysis of medical treatment

Interstitial Lung Disease: A Rare Association with Adult-Onset Still’s Disease

Common Skin Lesions of the Face

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