Lichen Planus following Hepatitis B Vaccination in an African Girl

Daramola, O O M; Ogunbiyi, Adebola; George, A. O.

doi:10.1177/004947550203200227

Cited by 9 publications

(10 citation statements)

References 15 publications

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“…A possible explanation for this decrease may be the success obtained by primary care physicians with the use of corticosteroids as first‐line management for pruritic conditions, 23 and hence a decrease in referral. Although previous studies have shown an association with hepatitis B 24 and C 25 infection, studies performed recently in our environment did not show any statistical association between lichen planus and these viruses; 26 however, one patient developed lichen planus after hepatitis B vaccination 27 …”

Section: Discussioncontrasting

confidence: 79%

Prevalence of skin diseases in Ibadan, Nigeria

2003

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Allergic conditions have increased; connective tissue disorders, such as systemic lupus erythematosus, scleroderma, and discoid lupus erythematosus, have also increased. Cutaneous disorders associated with human immunodeficiency virus infection, such as seborrheic dermatitis, have increased. Health workers need to be educated on the management and treatment of these conditions, and should be advised to refer patients to appropriate health facilities when necessary.

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Section: Discussioncontrasting

confidence: 79%

Prevalence of skin diseases in Ibadan, Nigeria

2003

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“…The mean age of LP patients in the present study was 37.20±13.39 years, that being in accordance with the previously documented adult age range of 30-60 years (24,25). Similarly, the mean age of patients with LP in this study was very close to 37.13±12.8 years as documented by Daramola et al previously in a similar environment (15)(16)(17) and 38.8 years as documented in India by Bhattacharya et al (26). There was no age difference between CLP and HLP patients.…”

Section: Discussionsupporting

confidence: 92%

“…Few Nigerian studies have detailed the epidemiology of LP (13)(14)(15)(16)(17), but none has examined the differences or peculiarities of CLP and HLP. The main aim of this study is to research into any existing demographic, clinical and histologic differences between CLP and HLP and to determine the clinical correlates of both types of LP among patients attending the Dermatology Clinics of two Nigerian Teaching Hospitals located in southeastern and southwestern Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic and Clinical Differences Between Classic and Hypertrophic Lichen Planus in Nigeria

Ifeanyi

Akinboro

Ezejoifor

et al. 2019

Serbian Journal of Dermatology and Venereology

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Introduction. Lichen planus is a chronic inflammatory skin disease known to have several clinical variants with attended variable clinical outcomes. Certain complications have been observed in the hypertrophic type, which were not found in association with the classic variant. Objective: To identify the epidemiologic and clinical differences between the classic and hypertrophic lichen planus and clinical correlates. Material and Methods. Of 104 participants with lichen planus included in the study, 49 had classic and 55 hypertrophic lichen planus. Demographic and clinical information was obtained. Diagnosis of lichen planus was made clinically and confirmed with histology. The participants were screened for metabolic syndrome, hepatitis B, and C. Results: Mean age of all patients was 37.20±13.39 years, with no age and gender differences between the participants with classic and hypertrophic lichen planus. Classic lichen planus was more likely to be painful, (8.2% vs 0.0, p=0.046), generalized (95.9% vs 16.4%, p<0.001), involve the oral mucosa (38.8% vs 0.0, p<0.001), the nails (38.8% vs 1.8, p<0.001), present with kobnerisation (55.1% vs 5.5%,<0.001), Wickhiam striae (69.4% vs 16.4%, p<0.001), associated with Hepatitis B vaccination (16.3% vs 3.6%, p<0.028) and anti HCV positivity (16.3% vs 0.0%, p=0.002). Hypertrophic lichen planus was significantly associated with impaired glucose tolerance/diabetes mellitus (16.4% vs 2.0%, p=0.013), dyslipidemia (74.5% vs 40.8%, p=0.001) and saw-tooth histologic appearance compared to classic type. Conclusion: Hypertrophic lichen planus is more likely to be associated with metabolic complications compared to the classic type. Further studies are needed to loink this difference t chronic inflamation.

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“…Furthermore, it is noteworthy to mention that Hepatitis B is currently a routine vaccine inclusive in the immunization schedule for the newborn in Nigeria. Occurrences of LP secondary to the vaccine (Engerix B) have been reported (22), yet from this series no LP was found to be secondary to Hepatitis B vaccine immunization.…”

Section: Discussionmentioning

confidence: 55%

Lichen Planus in African Children: A Study of 13 Patients

Nnoruka

2007

Pediatric Dermatology

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Lichen planus is an uncommonly encountered dermatosis in children, reported worldwide, however in sub-Saharan Africa there is paucity of data on Lichen planus among children. The aim of this study was to document the clinical types of Lichen planus observed in children in South East Nigeria from 1998 to 2001; and to highlight any differences and similarities with adult disease. In all, 13 patients (eight boys and five girls) aged between 3 and 15 years were diagnosed with Lichen planus. The limbs were the most common sites of involvement for nine (69.2%) children. Classic Lichen planus was the commonest clinical variant in eight (61.5%), while extensive hypertrophic plaques were observed in three (23.1%), linear lesions in two (15.4%) and eruptive generalized Lichen planus in two (15.4%). Koebner phenomenon was documented in five (38.5%); mucosal involvement, which is very uncommon in children affected by this disease, occurred in three (23.1%). Only one child had pterygium formation in all 20 nails (total nail dystrophy). No child had scalp or palmoplantar involvement. Despite the endemicity of hepatitis B surface antigen in our environment, this study also revealed that liver function tests were not significantly different between children with Lichen planus and hepatitis B surface antigen and those who were negative for this antigen; while anti-hepatitis C virus seropositivity was not recorded in any of these children.

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Lichen Planus following Hepatitis B Vaccination in an African Girl

Cited by 9 publications

References 15 publications

Prevalence of skin diseases in Ibadan, Nigeria

Prevalence of skin diseases in Ibadan, Nigeria

Epidemiologic and Clinical Differences Between Classic and Hypertrophic Lichen Planus in Nigeria

Lichen Planus in African Children: A Study of 13 Patients

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