“…32 Correct diagnosis can be challenging, because oesophageal biopsies may not capture the histological findings. 30,32 Association with squamous cell carcinoma has been observed in less than 20 patients, but causation is not always established. 28,30,33,34 Oesophageal LP should be considered in the differential diagnosis of dysphagia or stenosis/stricture in elderly aged women with or without cutaneous lesions of LP.…”
Section: Gi Involvement In Lichen Planus (Lp)mentioning
confidence: 99%
“…It usually involves the proximal or mid‐oesophagus, but multiple involvement is possible 32 . Correct diagnosis can be challenging, because oesophageal biopsies may not capture the histological findings 30,32 . Association with squamous cell carcinoma has been observed in less than 20 patients, but causation is not always established 28,30,33,34 .…”
Section: Gi Involvement In Lichen Planus (Lp)mentioning
confidence: 99%
“…Around 20% of the affected patients exhibit oesophageal LP as the sole or first involvement of LP 28 . It usually involves the proximal or mid‐oesophagus, but multiple involvement is possible 32 . Correct diagnosis can be challenging, because oesophageal biopsies may not capture the histological findings 30,32 .…”
Section: Gi Involvement In Lichen Planus (Lp)mentioning
Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Oesophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic oesophagitis, lichen planus and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic oesophagitis is an emerging chronic atopic disease with oesophageal dysfunction as the typical presentation, and oesophageal narrowing, rings and stricture as late complications. Oesophageal lichen planus mainly involves the proximal to mid-oesophagus in elderly aged women with long-term oral mucosal lesions. In acute attack of pemphigus vulgaris, oesophageal involvement is not uncommon but often neglected and may cause sloughing oesophagitis (oesophagitis dissecans superficialis) with acute GI bleeding in rare cases. GI manifestation of hereditary bradykininergic angio-oedema with colicky acute abdomen mostly affects small intestine, usually in the absence of pruritus or urticaria, and is more severe and long-lasting than the acquired histaminergic form. Strong evidence supports association between inflammatory bowel disease, especially Crohn disease, and hidradenitis suppurativa/acne inversa. Patients with vitiligo need surveillance of autoimmune liver disease, autoimmune atrophic gastritis or coeliac disease when corresponding symptoms become suspect. Melanoma is the most common primary tumour metastatic to the GI tract, with small intestine predominantly targeted. Gastrointestinal involvement is not uncommon in disseminated mycosis fungoides. Extramammary Paget's disease is an intraepidermal adenocarcinoma of controversial origin, and a high association between the anogenital occurrence and colorectal adenocarcinoma has been reported. As GI tract is the largest organ system with multidimensional functions, dermatologists in daily practice should be aware of the gastrointestinal morbidities related to primary skin diseases for an early diagnosis and treatment.
“…32 Correct diagnosis can be challenging, because oesophageal biopsies may not capture the histological findings. 30,32 Association with squamous cell carcinoma has been observed in less than 20 patients, but causation is not always established. 28,30,33,34 Oesophageal LP should be considered in the differential diagnosis of dysphagia or stenosis/stricture in elderly aged women with or without cutaneous lesions of LP.…”
Section: Gi Involvement In Lichen Planus (Lp)mentioning
confidence: 99%
“…It usually involves the proximal or mid‐oesophagus, but multiple involvement is possible 32 . Correct diagnosis can be challenging, because oesophageal biopsies may not capture the histological findings 30,32 . Association with squamous cell carcinoma has been observed in less than 20 patients, but causation is not always established 28,30,33,34 .…”
Section: Gi Involvement In Lichen Planus (Lp)mentioning
confidence: 99%
“…Around 20% of the affected patients exhibit oesophageal LP as the sole or first involvement of LP 28 . It usually involves the proximal or mid‐oesophagus, but multiple involvement is possible 32 . Correct diagnosis can be challenging, because oesophageal biopsies may not capture the histological findings 30,32 .…”
Section: Gi Involvement In Lichen Planus (Lp)mentioning
Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Oesophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic oesophagitis, lichen planus and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic oesophagitis is an emerging chronic atopic disease with oesophageal dysfunction as the typical presentation, and oesophageal narrowing, rings and stricture as late complications. Oesophageal lichen planus mainly involves the proximal to mid-oesophagus in elderly aged women with long-term oral mucosal lesions. In acute attack of pemphigus vulgaris, oesophageal involvement is not uncommon but often neglected and may cause sloughing oesophagitis (oesophagitis dissecans superficialis) with acute GI bleeding in rare cases. GI manifestation of hereditary bradykininergic angio-oedema with colicky acute abdomen mostly affects small intestine, usually in the absence of pruritus or urticaria, and is more severe and long-lasting than the acquired histaminergic form. Strong evidence supports association between inflammatory bowel disease, especially Crohn disease, and hidradenitis suppurativa/acne inversa. Patients with vitiligo need surveillance of autoimmune liver disease, autoimmune atrophic gastritis or coeliac disease when corresponding symptoms become suspect. Melanoma is the most common primary tumour metastatic to the GI tract, with small intestine predominantly targeted. Gastrointestinal involvement is not uncommon in disseminated mycosis fungoides. Extramammary Paget's disease is an intraepidermal adenocarcinoma of controversial origin, and a high association between the anogenital occurrence and colorectal adenocarcinoma has been reported. As GI tract is the largest organ system with multidimensional functions, dermatologists in daily practice should be aware of the gastrointestinal morbidities related to primary skin diseases for an early diagnosis and treatment.
“…Although classic lichen planus is a common disease, there are very few reported cases of three or more forms of lichen planus occurring simultaneously in an individual [ 4 ]. Here we present a case of cutaneous lichen planus occurring in five different forms: classic, hypertrophic, annular, bullous, and pigmentosus, all in one patient at the time of presentation.…”
Lichen planus is a common dermatological condition. It is described as a chronic inflammatory mucocutaneous disease that has characteristic clinical and histopathological findings. Classical lichen planus lesions occur as purple, pruritic polygonal papules or plaques with a lace-like pattern of whitish markings on the surface. Despite the large number of variants that exist with different clinical manifestations from the classic form, histopathology features are fairly similar among the subtypes and can aid in the diagnosis. Although most cases of lichen planus are often self-limiting with spontaneous resolution expected within one to two years, early diagnosis and treatment are encouraged to control severe pruritus and painful mucosal erosion, but most importantly to minimize the potential for malignant transformation in long-standing lesions. The main objective of this paper is to report the first case of five cutaneous variants of lichen planus occurring simultaneously in a young male patient.
“…Lichen planus is a chronic inflammatory disease, manifested by monomorphic papular rash on the skin and mucous membranes, characterized by mild to severe itching [1][2][3] . Classic lesions of LP are flat-topped, polygonal, violaceous papules and plaques with fine white lines called Wickham striae most commonly affecting the skin and oral mucosa 4,5 . Lichen planus (LP) is also characterized by frequent relapses, development of severe, torpid forms of the disease, affecting the patients' working capacity and quality of life 6,7 .…”
Étude du rôle de l'homocystéine et d'autres marqueurs de l'intoxication endogène dans la pathogenèse du développement du lichen planIntroduction. Le lichen plan (LP) est une dermatose poly-étiologique chronique selon son mécanisme d'apparition qui se manifeste par une éruption papuleuse sur la peau et les muqueuses, ainsi que par des démangeaisons intenses. L'objectif de cette étude est d'identifier et d'analyser le niveau de marqueurs d'intoxication endogène dans le plasma sanguin de patients atteints de lichen plan selon la gravité et la durée de la maladie. Matériaux et méthodes. Nous avons surveillé 48 patients atteints de LP: 20 hommes et 28 femmes. Chez 31 patients, la dermatose a duré moins de 2 ans, chez 17 patients -plus de 2 ans. Un faible degré de LP a été diagnostiqué chez 17 patients, un moyen -chez 31. On a déterminé dans le sang de tous les patients les taux de l'homocystéine (Hcy), des carbonyles des protéines modifiées par oxydation (C-PMO) et des peptides d'un poids moléculaire moyen (PPMM).
ABSTRACTIntroduction. Lichen planus (LP) is a chronic poly-etiologic dermatosis by the mechanism of its development, manifested by papular rash on the skin and mucous membranes, severe itching. The objective of the study was to determine and analyze the levels of endogenous intoxication markers in blood plasma of the patients with lichen planus depending on severity and duration of the disease. Materials and methods. 48 patients, 20 men and 28 women, participated in the study. 31 patients had suffered from dermatosis for about 2 years, and 17 patients for over 2 years. Mild LP was diagnosed in 17 patients and moderate LP in 31 patients. The blood levels of homocysteine (HC), carbonyl groups of oxidative modified proteins (CG-OMP) and medium molecular weight peptides (MMWP) were determined in all the patients. Results. Significantly increased blood plasma levels of HC, MMWP and CG were found in patients with lichen planus as compared to the control group. The patients with severe and prolonged course of dermatosis had more evident disturbances in the content
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