Lichen planus associated with neoplasia: A cell-mediated immune response to tumor antigens?

Helm, Thomas N.; Camisa, Charles; Liu, Aries Y.; Valenzuela, Rafael; Bergfeld, Wilma F.

doi:10.1016/s0190-9622(94)70020-6

Cited by 46 publications

(30 citation statements)

References 16 publications

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“…Finally, specific traumas may also induce the occurrence of lichen ruber planus, known as Koebner's phenomenon in memory of the dermatologist who first described it. Manifestation of lichen ruber planus in the context of malignancy is very rare [6]. In 2005, Sciallis et al [7] reported on the case of a 68-year-old man with metastatic breast cancer presenting with progressive linear lichen planus.…”

Section: Discussionmentioning

confidence: 99%

Generalized Lichen Ruber Planus – Induced by Radiotherapy of the Breast?

Eichbaum¹,

Harms²,

Bolz

et al. 2006

Oncol Res Treat

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Lichen ruber planus is an inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. The etiology is unknown. Patients and Methods: A 56-year-old female was treated with standard local radiotherapy after breast-conserving surgery due to high-grade ductal carcinoma in situ (DCIS) of the breast. Results: During radiotherapy, the patient began to complain about increasing disseminated itching papules of the breast. The efflorescences appeared as flat-topped, solid, purplish papules spreading to the limbs and trunk. A thorough clinical examination revealed additionally suspicious cob-web like and white-coated mucosal lesions of the oral cavity consistent with the clinical diagnosis of a generalized lichen ruber planus with an oral manifestation. Conclusion: To our knowledge, this is the first report of a generalized manifestation of lichen ruber planus presumably induced by radiation therapy.

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Section: Discussionmentioning

confidence: 99%

Generalized Lichen Ruber Planus – Induced by Radiotherapy of the Breast?

Eichbaum¹,

Harms²,

Bolz

et al. 2006

Oncol Res Treat

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“…Grinspan described seven cases of OLP associated with diabetes and hypertension (Grinspan et al, 1966), a triad which became known as Grinspan's syndrome. This is still seen but is probably a coincidental combination of the three common disorders or may be a lichenoid reaction provoked by the drugs used to control diabetes or hypertension (Lamey et al, 1990 (Helm et al, 1994), retroperitoneal sarcoma (Helm et al, 1994), stomach cancer (Okoki et al, 1990), thymoma (Tan, 1974a,b;Aronson et al, 1978;Flamenbaum et al, 1982;Cottoni et al, 1988;Helm et al 1994), Castleman's tumor (Ashinoff et al, 1989;Jansen et al, 1995), craniopharyngioma (Magnusson, 1967), pituitary adenoma (Magnusson, 1967), and non-Hodgkin's lymphoma (Feuerman and Sandbank, 1971;Helm et al, 1994).…”

Section: (8) Stressmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

458

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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“…The proposed mechanisms linking tumor and lichen planus-like lesions was that foreign antigens expressed on the tumor, cross-reacted with the epidermal antigens and induced the autoantibody reactive T-lymphocytes [3] or that tumors associated with PNP produced excessive/abnormal plakin proteins that then became autoantigens [4]. An alternative explanation for this autoimmune reaction is epitope spreading [5].…”

Section: A New Understanding Of the Role Of Pathogenic B-cells From Tmentioning

confidence: 99%