Lichen Myxedematosus (Differentiation from Cutaneous Myxedemas or Mucoid States)

Montgomery, Hamilton; Underwood, Laurence J.

doi:10.1038/jid.1953.25

Cited by 172 publications

(61 citation statements)

References 38 publications

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“…1,2 The myxedematous lichen spectre (papular mucinosis) was originally described by Dubreuilh and Reitman, in 1906. 3 In 1953, Montgomery and Underwood 4 classified the myxedematous lichen into four clinical forms: (1) generalized lichenous papular eruption; (2) nonconfluent papular form; (3) localized or generalized lichenous plaques; and (4) urticaria-like plaques and nodular lichenous eruptions.…”

Section: Introductionmentioning

confidence: 99%

Escleromixedema: um caso tratado com prednisona oral

Neto

Sales

Silva

et al. 2006

An. Bras. Dermatol.

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Scleromyxedema is an idiopathic cutaneous mucinosis characterized by a papular eruption, skin induration and paraproteinemia. Histologically, fibrolast proliferation can be observed in the upper dermis associated with a mucine deposition. Treatment is difficult and at present there is no totally effective therapeutic modality to control the disease. The present report is on a 68-year-old patient with scleromyxedema without systemic manifestation, who responded to oral steroid therapy.

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Section: Introductionmentioning

confidence: 99%

Escleromixedema: um caso tratado com prednisona oral

Neto

Sales

Silva

et al. 2006

An. Bras. Dermatol.

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“…LM (Lichen myxoedematosus), first described in 1906, [10] was earlier classified in 1953 by Montgomery and Underwood into four subtypes: (i) Generalized lichenoid papular eruption, (ii) discrete papular form, (iii) localized-togeneralized lichenoidplaques, and (iv) urticarial plaques and nodular eruptions. [11,12] LM was reclassified in 2001 into a) generalized form called scleromyxoedema, which is usually associated with monoclonal gammopathy; b) localized forms without demonstrable paraproteins are further classified into five types that are-(i) discrete papular LM, (ii) acral persistentpapular mucinosis (APPM), (iii) self-healing papular mucinosis, (iv) papularmucinosis of infancy, and (v) nodular LM; and c) atypical forms are further classified as(i) scleromyxoedema without monoclonalgammopathy, (ii) localized LM with monoclonal gammopathy, (iii)localized LM with mixed features of different subtypes, and (iv) not otherwise specified variety. [3] Discrete papular mucinosis has no gender predilection and lesions are present on trunk and limbs.…”

Section: Discussionmentioning

confidence: 99%

“…[2,13] Although it was described as a distinct clinical and histological form of cutaneous mucinosis in 1986, [4] suchlesions had been previously described by Montgomery and Underwood in 1953. [11] Diagnostic criteria of APPM were proposed by Harriset al [2] The lesions tend to persist and may increase slowly, but systemic involvement does not occur. [2,[14][15][16] They mainly involve the back of the hands and wrists, the distal aspects of the forearms, and rarely the antecubital fossae.…”

Section: Discussionmentioning

confidence: 99%

Acral Persistent Papular Mucinosis in Indian Patient: Rare Presentation with Review of Literature

Chauhan¹

2017

jmscr

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“…1953 y›l›nda Montgomery ve Underwood'un liken miksödematozu s›n›f-lamas›n›n ard›ndan 2001 y›l›nda Rongioletti yeni bir s›n›fla-ma ile liken miksödematoz ve subtipleri için tan› kriterlerini ortaya koymufltur. Bu s›n›flamaya göre iki klinikopatolojik subtip vard›r: (i) generalize papüler ve sklerodermoid form (skleromiksödem) ve (ii) lokalize papüler form 1,3 . Skleromiksödem için tan› kriterleri: (1) generalize papüler ve sklerodermoid erüpsiyon: (2) müsin birikimi, fibroblast proliferasyonu ve fibrozis: (3) monoklonal gammopati varl›¤› ve (4) tiroid hastal›¤› olmamas›d›r.…”

Section: Tart›flmaunclassified

"Diskret" Papüler Müsinoz: Liken Miksödematozun Nadir Bir Subtipi

Akış¹,

Eskioğlu²,

Öztürk³

2011

Turkderm

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ÖzetLiken miksödematoz (papüler müsinoz) tiroid hastal›¤› olmaks›z›n dermal müsin birikimi ve fibrozise ba¤l› olarak geliflen likenoid papül, nodül ve/veya plaklar ile karakterize s›k görülmeyen, kronik, idiyopatik bir hastal›kt›r.Liken miksödematoz klinikopatolojik olarak iki subgrup içerir: monoklonal gammopati ile beraber sistemik, hatta letal bulgular› olan generalize papüler ve sklerodermoid form (skleromiksödem de denir) ve daha selim prognozlu lokalize papüler form."Discrete" papüler müsinoz, Hepatit C virüs (HCV) ve insan immünyetmezlik virüs (HIV) infeksiyonu ile iliflkili olabilen lokalize formun nadir bir subtipidir.Bugüne kadar literatürde HCV veya HIV infeksiyonu ile iliflkisi olmayan sadece 12 olgu bildirimi vard›r. Burada vücu-dunda çok say›da, asemptomatik, deri renginde papülleri olan, histopatolojik incelemede dermal müsin birikimi tespit edilen, tiroid hastal›¤› ve monoklonal gammopati saptanmayan, viral belirleyicileri negatif olan 64 yafl›nda kad›n hastay› sunuyoruz. SummaryLichen myxoedematosus (synonym, papular mucinosis) is an uncommon, chronic, idiopathic disorder characterized by lichenoid papules, nodules and/or plaques due to dermal mucin deposition and a variable degree of fibrosis in the absence of thyroid dysfunction. Actually, lichen myxoedematosus includes two clinicopathologic subsets: a generalized papular and sclerodermoid form (also called scleromyxedema) with a monoclonal gammopathy and systemic, even lethal, manifestations and a localized papular form with non-disabling course. Discrete papular mucinosis is a rare subtype of the localized form and can be associated with hepatitis C virus and human immunodeficiency virus (HIV) infection. Only 12 cases unrelated to HCV or HIV infection have been described in the literature to date. Herein, we report a 64-year-old woman who presented with asymptomatic, flat, flesh-coloured papules on her neck, upper trunk and proximal extremities. A skin biopsy from a papule on her neck demonstrated dermal mucin deposition after alcian blue staining. The number of fibroblasts was increased. Laboratory studies revealed normal thyroid function tests. Serum protein electrophoresis did not show any evidence of a monoclonal gammopathy. Serology tests for HCV and HIV were negative. (Turkderm 2011; 45: 104-6)

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Lichen Myxedematosus (Differentiation from Cutaneous Myxedemas or Mucoid States)

Cited by 172 publications

References 38 publications

Escleromixedema: um caso tratado com prednisona oral

Escleromixedema: um caso tratado com prednisona oral

Acral Persistent Papular Mucinosis in Indian Patient: Rare Presentation with Review of Literature

"Diskret" Papüler Müsinoz: Liken Miksödematozun Nadir Bir Subtipi

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