Lichen aureus

Büchner, S.A.

doi:10.1159/000249596

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…Although the rate of healthy carriers varies between 11.9 and 72.0% [2, 3], skin symptoms caused by these mites appear to develop only in predisposed people [4]. It has been postulated that cell-mediated immune response plays an important role in the pathogenesis of Demodex mite infestation [5, 6]. The increased frequency of demodicosis, which was associated with immunocompromised hosts, e.g.…”

Section: Introductionmentioning

confidence: 99%

The Role of HLA A2 and Cw2 in the Pathogenesis of Human Demodicosis

Mumcuoglu¹,

Akilov²

2005

Dermatology

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Background: Demodicosis is a chronic skin disease caused by parasitic mites of the genus Demodex. It usually affects the face area causing major esthetical problems. The pathogenesis of demodicosis is not fully understood; however, it is quite apparent that immunological mechanisms mediate its development. Objective: The goal of this study was to study the correlation between immunological and immunogenetic data obtained from patients with demodicosis in order to clarify the pathogenesis of Demodex infestation. Methods: Twenty-five patients with demodicosis and 13 age- and sex-matched healthy subjects participated in the study. The presence of mites was determined by microscopic inspection of sebum gland secretions. The immune response was evaluated by identifying membrane markers of different immune cells using monoclonal antibodies (anti-CD3+, CD4+, CD8+, CD16+, CD20+ and CD95+) while the concentration of IgA, IgM and IgG was measured by simple radial immunodiffusion. The level of circulating immune complexes and total hemolytic complement as well as the preparatory and digestive function of neutrophils and the functional activity of leukocytes were also studied. Patients were typed for HLA A, B, Bw and Cw using the microlymphocytotoxicity method. Results: The comparison between patients with and without the A2 phenotype showed that the latter have lower numbers of CD8+, lower functional activity of leukocytes, higher concentrations of IgA, larger affected skin areas and are more often affected by deep papular and papulopustular forms of demodicosis than those with the A2 phenotype, showing that this allele has a protective role in demodicosis. Patients exhibiting the Cw2 phenotypes were rather susceptible to demodicosis. They showed decreased numbers of CD3+, increased levels of phagocytic activity, higher mite density and severer skin damage as compared to patients lacking Cw2. Conclusions: The HLA A2 and Cw2 phenotypes have an important diagnostic, prognostic and pathogenetic significance and could play a role in resistance or susceptibility to demodicosis by regulating the end phase of the immune response.

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Section: Introductionmentioning

confidence: 99%

The Role of HLA A2 and Cw2 in the Pathogenesis of Human Demodicosis

Mumcuoglu¹,

Akilov²

2005

Dermatology

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“…Cansaço ele não tinha, apenas lhe era desagradável, às vezes, não poder andar de ponta cabeça". 13 Celan cita e comenta Lenz:…”

Section: Crítica Literária Outras Artes E Mídiasunclassified

Ir pelo eu para além do eu: a poética em curso de Paul Celan

Ferreira

2013

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Paul Celan concebe O meridiano como discurso de agradecimento ao Prêmio Georg Büchner, de 1960. Porém, o texto de Celan transcende o caráter laudatório da ocasião com uma reflexão ampla sobre a arte. Para tanto, Celan incorpora a obra do próprio Georg Büchner, como meio e objeto de seus comentários. Na superfície, O meridiano assemelha-se a um tratado de arte poética, mas com a diferença marcante de que emprega, simultaneamente, os preceitos que elabora. No presente artigo O meridiano é debatido em sua relação com o drama de Büchner, bem como analisado em seus desdobramentos internos, como poética em curso.

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Demodex-Follikulitis

Rufli¹

1999

Vorträge Und Dia-Klinik Der 16. Fortbildungswoche 1998 Fortbildungswoche Für Praktische Dermatologie Und Venerologie e.V. C/O K

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Lichen aureus

Abstract: A 21 -year-old male patient with lichen aureus on the lower extremities is described. The clinical and histological features of this rarest of the pigmented and purpuric eruptions consisting of lichenoid papules and plaques are discussed.

Cited by 5 publications

References 5 publications

The Role of HLA A2 and Cw2 in the Pathogenesis of Human Demodicosis

The Role of HLA A2 and Cw2 in the Pathogenesis of Human Demodicosis

Ir pelo eu para além do eu: a poética em curso de Paul Celan

Demodex-Follikulitis

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