“…The claim has been made that at low doses meprobamate has significant effects on limbic structures before excitability in the midbrain reticular formation, or before the cortex shows marked changes (KLETZIN and SWAN, 1959). WINFIELD and AIVAZIAN (1961), GIBBS and GIBBS (1962), ROLDAN and ESCOBAR (1961), SCHALLECK and KUEHN (1965), HERNANDEZ-PEON et al (1964), and REQUIN et al (1963) have been reported fast EEG activity both in patients and animals treated with chlordiazepoxide even though behaviorally the subjects showed relaxation. Thus, there are data suggesting that chlordiazepoxide does not primarily act on the structures associated with sleep-wakefulness mechanisms, but on those implicated generally in the modulation of emotional behavior, and that, far from causing sedation as evidenced by EEG synchrony and decreased amplitude of evoked responses from stimulation of the mesencephalic reticular formation, it often causes EEG desynchronization not always associated with motor hyperactivity.…”