Capella University, an online university, started its library liaison program in 2007. The goals of the program were to increase the use of library resources and services and promote integration of information literacy competencies into coursework. A review of the literature of liaison programs shows a focus on liaison activities in traditional colleges and universities. While some activities are adaptable to the online environment, this setting provides unique opportunities for enhancing the impact of the liaison relationship. This article will describe key initiatives in three areas: the online course room, reference transactions, and collaboration with both academic and nonacademic departments. Strategies, activities, and tools used to implement the initiatives will be discussed.