Libby vermiculite exposure and risk of developing asbestos-related lung and pleural diseases

Antao, Vinicius C.; Larson, Theodore; Horton, D. Kevin

doi:10.1097/mcp.0b013e32834e897d

Cited by 45 publications

(26 citation statements)

References 22 publications

(29 reference statements)

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“…Non-malignant effects of asbestos exposure include respiratory symptoms, reductions in lung function, pleural plaques, pleural effusions, diffuse pleural thickening (DPT) and asbestosis (asbestos-related interstitial fibrosis). As pleural plaques can occur even after relatively low exposure, these are among the most common of the nonmalignant effects (Antao et al, 2012;Chapman et al, 2003;Clarke et al, 2006;Crapo, 2005;Cugell & Kamp, 2004;Epstein, 1984;Evans & Gleeson, 2004;Hillerdal, 1981Hillerdal, , 1994Hillerdal, , 1997Hourihane et al, 1966;IIAC, 2008;Jakobsson, 1993;Jakobsson et al, 1995;Jones, 1997;Myers, 2012;Roach et al, 2002;Sargent et al, 1977). Most researchers conclude that pleural plaques (alone) ''are nearly always asymptomatic' ' (British Thoracic Society, 2011) and ''are in themselves harmless and can be regarded as an objective sign of previous asbestos inhalation'' (Hillerdal & Henderson, 1997).…”

Section: Introductionmentioning

confidence: 99%

Are pleural plaques an appropriate endpoint for risk analyses?

Maxim¹,

Niebo²,

Utell

2015

Inhalation Toxicology

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This review summarizes the literature on the relation between the development of pleural plaques and non-malignant and malignant disease in cohorts exposed to asbestos and other fibers. The available evidence indicates that, absent any other pleural disease, the presence of pleural plaques does not result in respiratory symptoms or clinically significant impacts on lung function. For certain types of asbestos, the development of pleural plaques is statistically correlated with malignant disease, but the evidence is consistent with the hypothesis that pleural plaques without other pleural disease are a marker of exposure, rather than an independent risk factor. Pleural plaques have also developed in cohorts exposed to other fibers that have not proven to be carcinogenic. Risk analyses should be based on the avoidance of known adverse conditions, rather than pleural plaques per se.

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Section: Introductionmentioning

confidence: 99%

Are pleural plaques an appropriate endpoint for risk analyses?

Maxim¹,

Niebo²,

Utell

2015

Inhalation Toxicology

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“…Erionite, technically not asbestos but similar to a long thin amphibole fiber, found in white stucco and soil, in Turkey, has been associated with mesothelioma [35]. Proximity to industrial sources with some modification of exposure by wind direction has been reported as, for example, in Libby, Montana, the world’s largest vermiculite mine and processing operation [36]. Residents of Libby endured exposure to the vermiculite ore contaminated with amphibole asbestos resulting from past industrial production.…”

Section: Asbestosismentioning

confidence: 99%

“…Nonoccupational asbestos-related disease has been reported, such as among individuals with regular exposure to the clothes of asbestos workers and in individuals with environmental exposures to industrial sources as in Libby, Montana [36]. …”

Section: Diagnostic Work-upmentioning

confidence: 99%

Asbestosis and environmental causes of usual interstitial pneumonia

Gulati

Redlich²

2015

Current Opinion in Pulmonary Medicine

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Purpose of review Recent epidemiologic investigations suggest that occupational and environmental exposures contribute to the overall burden of idiopathic pulmonary fibrosis (IPF). This article explores the epidemiologic and clinical challenges to establishing exposure associations, the current literature regarding exposure disease relationships and the diagnostic work-up of IPF and asbestosis patients. Recent findings IPF patients demonstrate a histopathologic pattern of usual interstitial pneumonia. In the absence of a known cause or association, a usual interstitial pneumonia pattern leads to an IPF diagnosis, which is a progressive and often terminal fibrotic lung disease. It has long been recognized that asbestos exposure can cause pathologic and radiographic changes indistinguishable from IPF. Several epidemiologic studies, primarily case control in design, have found that a number of other exposures that can increase risk of developing IPF include cigarette smoke, wood dust, metal dust, sand/silica and agricultural exposures. Lung mineralogic analyses have provided additional support to causal associations. Genetic variation may explain differences in disease susceptibility among the population. Summary An accumulating body of literature suggests that occupational and environmental exposure can contribute to the development of IPF. The impact of exposure on the pathogenesis and clinical course of disease requires further study.

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“…17 Limitations of the TAR include potential self-selection bias and the lack of individual exposure measures for most participants, especially household contacts and other Libby residents. A strength of the TAR is that it includes a large proportion of the potentially affected population of this relatively small and isolated community.…”

Section: Examples Of Environmental Health Registriesmentioning

confidence: 99%

Considerations Before Establishing an Environmental Health Registry

et al. 2015

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Public health registries can provide valuable information when health consequences of environmental exposures are uncertain or will likely take long to develop. They can also aid research on diseases that may have environmental causes that are not completely well defined. We discuss factors to consider when deciding whether to create an environmental health registry. Those factors include public health significance, purpose and outcomes, duration and scope of data collection and availability of alternative data sources, timeliness, availability of funding and administrative capabilities, and whether the establishment of a registry can adequately address specific health concerns. We also discuss difficulties, limitations, and benefits of exposure and disease registries, based on the experience of the Agency for Toxic Substances and Disease Registry.

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Libby vermiculite exposure and risk of developing asbestos-related lung and pleural diseases

Cited by 45 publications

References 22 publications

Are pleural plaques an appropriate endpoint for risk analyses?

Are pleural plaques an appropriate endpoint for risk analyses?

Asbestosis and environmental causes of usual interstitial pneumonia

Considerations Before Establishing an Environmental Health Registry

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