Li-doped bioglass® 45S5 for potential treatment of prevalent oral diseases

Palza, Humberto; Cid, René Castro; Dosque, Mario Diaz; Ibacache, R Cabello; Fluxá, Patricia Palma

doi:10.1016/j.jdent.2020.103575

Cited by 15 publications

(12 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have to point out that the study results could have differed from our own on the basis of the test methodology, since actual cements containing TCS or lithium surface pre-reacted glass (S-PRG) particles were investigated in that study (Ali et al, 2022), unlike in our case where individual particles were evaluated. Elsewhere, excellent antimicrobial activity against a variety of oral bacteria was also reported for sol-gel synthesized 45S5 BAG that was doped with Li (Palza Cordero et al, 2021). The fact that the said study only considered BAG doped with 5% Li ion, may indicate that antimicrobial benefits of this ion are sufficient at concentrations as low as 5%.…”

Section: Haematoxylin and Eosin (Hande) Stainingmentioning

confidence: 97%

Sol-gel synthesis of lithium doped mesoporous bioactive glass nanoparticles and tricalcium silicate for restorative dentistry: Comparative investigation of physico-chemical structure, antibacterial susceptibility and biocompatibility

Simila

Boccaccını

2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Introduction: The sol-gel method for production of mesoporous bioactive glass nanoparticles (MBGNs) has been adapted to synthesize tricalcium silicate (TCS) particles which, when formulated with other additives, form the gold standard for dentine-pulp complex regeneration. Comparison of TCS and MBGNs obtained by sol-gel method is critical considering the results of the first ever clinical trials of sol-gel BAG as pulpotomy materials in children. Moreover, although lithium (Li) based glass ceramics have been long used as dental prostheses materials, doping of Li ion into MBGNs for targeted dental applications is yet to be investigated. The fact that lithium chloride benefits pulp regeneration in vitro also makes this a worthwhile undertaking. Therefore, this study aimed to synthesize TCS and MBGNs doped with Li by sol-gel method, and perform comparative characterizations of the obtained particles.Methods: TCS particles and MBGNs containing 0%, 5%, 10% and 20% Li were synthesized and particle morphology and chemical structure determined. Powder concentrations of 15mg/10 mL were incubated in artificial saliva (AS), Hank’s balanced saline solution (HBSS) and simulated body fluid (SBF), at 37°C for 28 days and pH evolution and apatite formation, monitored. Bactericidal effects against S. aureus and E. coli, as well as possible cytotoxicity against MG63 cells were also evaluated through turbidity measurements.Results: MBGNs were confirmed to be mesoporous spheres ranging in size from 123 nm to 194 nm, while TCS formed irregular nano-structured agglomerates whose size was generally larger and variable. From ICP-OES data, extremely low Li ion incorporation into MBGNs was detected. All particles had an alkalinizing effect on all immersion media, but TCS elevated pH the most. SBF resulted in apatite formation for all particle types as early as 3 days, but TCS appears to be the only particle to form apatite in AS at a similar period. Although all particles had an effect on both bacteria, this was pronounced for undoped MBGNs. Whereas all particles are biocompatible, MBGNs showed better antimicrobial properties while TCS particles were associated with greater bioactivity.Conclusion: Synergizing these effects in dental biomaterials may be a worthwhile undertaking and realistic data on bioactive compounds targeting dental application may be obtained by varying the immersion media.

show abstract

Section: Haematoxylin and Eosin (Hande) Stainingmentioning

confidence: 97%

Sol-gel synthesis of lithium doped mesoporous bioactive glass nanoparticles and tricalcium silicate for restorative dentistry: Comparative investigation of physico-chemical structure, antibacterial susceptibility and biocompatibility

Simila

Boccaccını

2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…The addition of Li did not affect the bioactivity of the BG, but enhanced the antibacterial effect over Aggregatibacter actinomycetemcomitans strain. BG‐Li presented a higher toxicity against A. actinomycetemcomitans than BG alone 56 …”

Section: Commercially Available Bg As Enamel Remineralization Agentsmentioning

confidence: 94%

“…BG-Li presented a higher toxicity against A. actinomycetemcomitans than BG alone. 56 10.14 | BG as sealants for pit and fissure enamel caries Enamel demineralization in the vicinity of pit and fissure sealants causes the formation of marginal caries, necessitating the replacement of older sealants. Sealants were added with BG-45S5 filler particles of size <25 μm and were found to exhibit acid neutralizing properties.…”

Section: Bg Doped With Lithiummentioning

confidence: 99%

Role of bioglass in enamel remineralization: Existing strategies and future prospects—A narrative review

2021

View full text Add to dashboard Cite

Enamel, once formed, loses the ability to regenerate due to the loss of the formative ameloblasts. It is subjected to constant damaging events due to exposure to external agents and oral microbiomes. An enamel remineralization process targets to replenish the lost ionic component of the enamel through a multitude of methods. Enamel remineralization is highly challenging as it has a complex organized hierarchical microstructure. Hydroxyapatite nanocrystals of the enamel vary in size and orientation along alignment planes inside the enamel rod. The inability of the enamel to remodel unlike other mineralized tissues is another substantial deterrent. One of the wellknown biomaterials, bioglass (BG) induces apatite formation on the external surface of the enamel in the presence of saliva or other physiological fluids. Calcium, sodium, phosphate, and silicate ions in BG become responsive in the presence of body fluids, leading to the precipitation of calcium phosphate. Studies have also demonstrated the bactericidal potential of BG against Streptococcus mutans biofilms. The anticariogenicity and antibacterial activity were found to be enhanced when BG was doped with inorganic ions such as F, Ag, Mg, Sr, and Zn. Due to the versatility of BG, it has been combined with a variety of agents such as chitosan, triclosan, and amelogenin to biomimic remineralization process. Key strategies that can aid in the development of contemporary enamel remineralization agents are also included in this review.

show abstract

“…To date, the antiviral activity of Li in different viruses (including porcine epidemic diarrhea, pseudorabies herpesvirus, Orthoreoviruses, and Coxsackievirus B3 virus) has been proved [ 193 , 194 , 195 , 196 ]. Additionally, its antibacterial activity against Gram-negative bacteria (including Porphyromonas gingivalis , Francisella tularensis , Aggregatibacter actinomycetemcomitans , Klebsiella pneumoniae , Escherichia coli , Burkholderia pseudomallei , and Pseudomonas aeruginosa ) and Gram-positive bacteria (including Streptococcus pneumoniae , Streptococcus mutans , and Staphylococcus aureus ) has been reported [ 197 , 198 , 199 , 200 , 201 , 202 ]. A summary of the biological effects of Li and the relation between these effects and autophagy is presented in Figure 5 .…”

Section: Lithium and Its Biological Effectsmentioning

confidence: 99%

“…Similar results were reported in a case report for zirconia-reinforced Li silicate (ZLS) [ 214 ]. The remineralization process induced by 45S5 Li-BG containing 5-wt% of Li and its great antibacterial activity is prevalent in oral diseases [ 202 ].…”

Section: Lithium-doped Bioceramics In Regenerative Medicinementioning

confidence: 99%

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Farmani

Salmeh

Golkar

et al. 2022

JFB

View full text Add to dashboard Cite

Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This element can be incorporated into the structure of various biomaterials through the inclusion of Li chloride/carbonate into polymeric matrices or being doped in bioceramics. The biocompatibility and multifunctionality of Li-doped bioceramics present many opportunities for biomedical researchers and clinicians. Li-doped bioceramics (capable of immunomodulation) have been used extensively for bone and tooth regeneration, and they have great potential for cartilage/nerve regeneration, osteochondral repair, and wound healing. The synergistic effect of Li in combination with other anticancer drugs as well as the anticancer properties of Li underline the rationale that bioceramics doped with Li may be impactful in cancer treatments. The role of Li in autophagy may explain its impact in regenerative, antiviral, and anticancer research. The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering. Such Li-doped biomaterials have significant clinical potential in the foreseeable future.

show abstract

Li-doped bioglass® 45S5 for potential treatment of prevalent oral diseases

Cited by 15 publications

References 45 publications

Sol-gel synthesis of lithium doped mesoporous bioactive glass nanoparticles and tricalcium silicate for restorative dentistry: Comparative investigation of physico-chemical structure, antibacterial susceptibility and biocompatibility

Sol-gel synthesis of lithium doped mesoporous bioactive glass nanoparticles and tricalcium silicate for restorative dentistry: Comparative investigation of physico-chemical structure, antibacterial susceptibility and biocompatibility

Role of bioglass in enamel remineralization: Existing strategies and future prospects—A narrative review

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Contact Info

Product

Resources

About