LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel
Maryline Beurg,
Evan Travis Schwalbach,
Robert Fettiplace
Abstract:During auditory transduction, sound-evoked vibrations of the hair cell stereociliary bundles open mechanotransducer (MET) ion channels via tip links extending from one stereocilium to its neighbor. How tension in the tip link is delivered to the channel is not fully understood. The MET channel comprises a pore-forming subunit, transmembrane channel-like protein (TMC1 or TMC2), aided by several accessory proteins, including LHFPL5 (lipoma HMGIC fusion partner-like 5). We investigated the role of LHFPL5 in trans… Show more
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