LH stimulation of estrogen secretion by cultured rat granulosa cells

Wang, C.; Hsueh, Aaron J. W.; Erickson, Gregory F.

doi:10.1016/0303-7207(81)90075-7

Cited by 44 publications

(19 citation statements)

References 30 publications

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“…Aromatase activity is, at least in part, a cAMP-dependent event [12]. In granulosa cells, cAMPdependent aromatase activity can be regulated by either FSH or LH [12,13]. In the present study, the mean diameters of the estrogenic follicles in both genotypes were -3 mm, and also in both genotypes granulosa cells with high aromatizing activity were recovered from follicles > 2.5 mm in diameter.…”

Section: Discussionmentioning

confidence: 51%

Plasma Gonadotropin Concentrations and Ovarian Characteristics in Inverdale Ewes that are Heterozygous for a Major Gene (FecX1) on the X Chromosome that Influences Ovulation Rate

Shackell

Hudson²,

Heath³

et al. 1993

Biology of Reproduction

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Ewes heterozygous (I+) for the Inverdale prolificacy gene (FecX1) located on the X chromosome have ovulation rates approximately 1.0 times higher than noncarriers (++). The aims of this study were to examine, in I+ and ++ ewes, the peripheral plasma concentrations and/or ovarian secretion rates of FSH, LH, inhibin, estradiol, and progesterone during anestrus and the estrous cycle and after ovariectomy. Also examined were aspects of ovarian morphology and functions of granulosa cells in vitro. No FecX1-specific differences were noted for the ovarian hormones or for FSH or LH. However, I+ animals contained significantly more ovarian antral follicles (p < 0.05) and their granulosa cells had a higher mean LH responsiveness in vitro with respect to cAMP synthesis at smaller follicular diameters relative to ++ ewes (I+ = > 2.5 mm; ++ = > 4.5 mm). Moreover, nonatretic follicles in I+ animals compared to the ++ genotype contained fewer granulosa cells and smaller CL. Although the I+ animals had a higher ovulation rate than the controls (p < 0.05), the total weight of CL was not different between the genotypes. These findings suggest that the FecX1 gene affects ovarian function without altering ovarian hormone secretion. The findings also suggest that there are no FecX1-specific differences in the mean concentrations of gonadotropins, although further studies on temporal changes in gonadotropin secretion are warranted.

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Section: Discussionmentioning

confidence: 51%

Plasma Gonadotropin Concentrations and Ovarian Characteristics in Inverdale Ewes that are Heterozygous for a Major Gene (FecX1) on the X Chromosome that Influences Ovulation Rate

Shackell

Hudson²,

Heath³

et al. 1993

Biology of Reproduction

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“…Therefore, we can propose that decreased LH and FSH would cause reduced reproductive function of female animals following Al exposure. The declined FSH and LH may decrease synthesis of aromatizing enzyme [33,34] to inhibit reproductive function through aggravating the synthesis of E 2 and P.…”

Section: Discussionmentioning

confidence: 98%

Effects of Subchronic Aluminum Exposure on the Reproductive Function in Female Rats

Wang

She

Zhu

et al. 2011

Biol Trace Elem Res

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The aim of this study was to investigate the effects of aluminum (Al) exposure on the reproductive function in female rats. Forty female Wistar (5 weeks old) rats, weighing 110-120 g, were divided randomly into four groups. They were orally administrated with 0, 64.18, 128.36, and 256.72 mg aluminum chloride (AlCl(3)) per kilogram body weight in drinking water for 120 days. Levels of Al, estrogen (E(2)), progestogen (P), testosterone (T), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in serum were measured at the end of experiment. The results showed that levels of E(2), P, FSH, and LH were significantly lower and Al concentration was significantly higher in all three Al-treated groups than those in the control group (GC). The level of T was significantly higher in the low- and medium-dose groups (GL and GM) (P < 0.05) but not in high-dose group (GH) compared with GC. The results suggest that the reproductive function of female rats is inhibited under long-term Al exposure in an Al dose-dependent manner.

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“…FSH has been implicated as the major hormone controlling aromatase activity of the granulosa cells in rodents (Armstrong & Dorrington, 1977), but LH has also been shown to maintain oestrogen production by granulosa cells (Wang et al, 1981) and by antral follicles (Shaban & Terranova, 1983). On the morning after the start of progesterone treatment, the antral follicles were histologically 'normal' (data not shown) thus excluding the possibility of the onset of atresia.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the acute effects of exogenous progesterone on the decline in oestradiol concentrations in serum were apparently mediated by a decrease in the circulating level of LH. Since LH controls thecal androgen production in developing and preovulatory follicles (Armstrong & Dorrington, 1977) and maintains, in part, aromatizing activity in granulosa cells of the rat (Wang, Hsueh & Erickson, 1981), the present study was designed to ascertain whether the progesterone-induced decline in oestradiol values was mediated by LH at the level of the theca, granulosa cell or both.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of thecal androstenedione production by exogenous progesterone in the cyclic hamster

Garza¹,

Terranova²

1984

Reproduction

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Summary. Implants of progesterone on the day of dioestrus II in the hamster induced on the following day an increase in circulating levels of progesterone (6\m=.\0\ m=+-\0\m=.\7ng/ml, N = 8; sesame oil controls, <0.5 ng/ml, N = 6) and a decline in serum levels of LH (5\m=.\3\ m=+-\ 0\m=.\4 ng/ml; controls 12 \ m=+-\ 2 ng/ml) and oestradiol (10 \ m=+-\ 2 pg/ml ; controls 69 \ m=+-\ 5 pg/ml). The production of androstenedione and oestradiol by antral follicles in vitro was reduced in progesterone-treated hamsters when compared with controls, but progesterone production was not affected. Aromatizing activities of antral follicles were the same in progesterone-treated and sesame oil-treated hamsters. Androstenedione production by theca was significantly less in progesterone-treated hamsters than in controls. On dioestrus II, LH replacement therapy (200 \ g=m\ g ovine LH by osmotic minipump inserted s.c.) prevented the decline in follicular androstenedione and oestradiol production induced by progesterone alone, and also prevented the decline in thecal androstenedione production in vitro. The results indicate that exogenous progesterone on dioestrus II lowers circulating levels of LH by the following day, inhibits thecal androstenedione production and thus reduces follicular oestradiol production without alteration in aromatizing ability.

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LH stimulation of estrogen secretion by cultured rat granulosa cells

Cited by 44 publications

References 30 publications

Plasma Gonadotropin Concentrations and Ovarian Characteristics in Inverdale Ewes that are Heterozygous for a Major Gene (FecX1) on the X Chromosome that Influences Ovulation Rate

Plasma Gonadotropin Concentrations and Ovarian Characteristics in Inverdale Ewes that are Heterozygous for a Major Gene (FecX1) on the X Chromosome that Influences Ovulation Rate

Effects of Subchronic Aluminum Exposure on the Reproductive Function in Female Rats

Inhibition of thecal androstenedione production by exogenous progesterone in the cyclic hamster

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