LH- and FSH Response to Long-Term Application of LH-RH Analogue in Normal Males

Wiegelmann, W.; Solbach, H. G.; Kley, H K; Krüskemper, H. L.

doi:10.1055/s-0028-1095583

Cited by 34 publications

(7 citation statements)

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“…Hence, the differential behavior of the LH response may be related to the different model of treatment in the two groups of patients. These results agree with the findings of Wiegelmann et al (1977).…”

Section: Discussionsupporting

confidence: 93%

Daily and Alternate‐day Treatment with an LHRH Analog in the Therapy of Idiopathic Hypogonadotropic Hypogonadism

Lombardi

Rosa

Torino

et al. 1984

Journal of Andrology

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Twenty‐five male patients with idiopathic hypogonadotropic hypogonadism were treated with 5μg of an LHRH analog (D‐Leu6‐Des‐Gly10‐LHRH‐ethylamide) intramuscularly for one month. The FSH and LH responses (quantitated as cumulative response areas) to acute LHRH intravenous administration (100 μg) were evaluated before and after each week of treatment. The patients were randomly divided into two groups: group A (16 patients) was treated every day; group B (nine patients) was treated every other day. Each group was divided into two subgroups (1 and 2), according to the degree of pretreatment LH response impairment. Patients in the first subgroup had a pretreatment cumulative response area greater than 3 SD below the mean for normal males. Patients in the second subgroup had a response less than 3 SD below the mean for normal males. Daily treatment produced a significant and progressive increase in LH response in subgroup A‐1, but in the second subgroup (A‐2) there was a maximal increase after the first and second week, with a subsequent decline. Alternate‐day treatment, on the other hand, produced a significant and progressive increase in LH response in all patients from subgroups B‐1 and B‐2. Both daily and alternate‐day treatments induced an initial increase in FSH response during the first week, followed by a progressive decline in all the groups. Finally, there was a lack of response to either form of treatment with regard to testosterone secretion and spermatogenesis. The findings indicate that LH response to LHRH analog differed depending on the degree of pretreatment pituitary impairment and the course of therapy followed.

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Section: Discussionsupporting

confidence: 93%

Daily and Alternate‐day Treatment with an LHRH Analog in the Therapy of Idiopathic Hypogonadotropic Hypogonadism

Lombardi

Rosa

Torino

et al. 1984

Journal of Andrology

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“…Chronic stimulation with D-Leu 6 -LH-RH EA or with D -S e r^u^-L H -R H EA can also lead to a decreased responsiveness of the pituitary gland (9,10,25,33,34,64,65,67). In normal men and women or in patients of either sex with various fertility disturbances, the initially high release of L H and FSH declined progressively to almost nil if the analogues were injected every day or several times each day.…”

Section: Antifertility Effects Of Superactive Lh-rh Analogues In H U mentioning

confidence: 99%

LH‐RH Agonists and Antagonists

Schally

Coy

Arimura

1980

Intl J Gynecology & Obste

100

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Large doses of stimulatory analogues of luteinizing hormone-releasing hormone (LH-RH) caused paradoxical antifertility effects. These effects are being utilized for the possible development of contraceptive methods. Several inhibitory analogues of LH-RH have been tested in men and women and shown to be active. The synthetic approach based on inhibitory analogues of LH-RH has been proven to be feasible for development of new methods of birth control. Continued research and testing along these lines may lead to the development of contraceptives based on inhibitory analogues of LH-RH that could be conveniently applied as a nasal spray and could be free of undesirable side effects.

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“…Several workers believe that whilst there is no impairment of the secretion of the readily releasable component of the two pituitary pools postulated by Bremner & Paulsen (1974), the agonist impairs the synthesis of new protein or hormone required for the release of the second pool (Fraser & Lincoln, 1980). Exhaustion of the pituitary gland pool is supported by Smith et al ( 1979) and by Weigelmann, Solbach, Kley & Kruskemper (1977) who showed that the rate at which the hypophysis becomes refractory to analogue is dose-dependent and can be reduced by decreasing the frequency or dose of analogue administration. Yet Bremner, Findlay, Lee, De Kretser & Cumming (1980) report that continued exposure of ram pituitary glands to Gn-RF results in a period of refractoriness and postulate that the presence of continuously high levels of Gn-RF for long periods may adversely affect the affinity of the pituitary receptors to releasing factor rather than the releasable pool itself being affected.…”

Section: Discussionmentioning

confidence: 99%

Repetitive Treatment With Gonadotrophin Releasing Factor or a Long-Acting Analogue Upon Gonadotrophin Secretion in the Ferret

Gledhill¹,

Donovan²

1981

Journal of Endocrinology

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The changes in plasma levels of LH and FSH were examined after treatment of intact and ovariectomized females ferrets with a long-acting analogue of gonadotrophin releasing factor (Gn-RF) (D-Ser(But)6-LH-releasing hormone (1-9)-nonapeptide ethylamide; Hoe 766) either as a single intravenous injection or daily for 6 days. The responses were compared with those induced by daily injections of Gn-RF or 0.9% NaCl (w/v). Treatment with Gn-RF consistently induced rises in both LH and FSH release with peak levels of both hormones being reached 20 min after injection and being of similar size from day to day in individual animals. Thereafter, the gonadotrophin levels declined rapidly to approach basal values by the end of each sampling period. Treatment with Hoe 766, however, produced very high values on day 1 of treatment, with LH being raised for 10-12 h and FSH for up to 24 h. Subsequent injections, on the other hand, produced an abbreviated LH response of similar size to that induced by Gn-RF and little, if any, FSH response. In ovariectomized ferrets, Hoe 766 induced a variable LH response and little FSH response at any time. In addition, basal FSH levels in the first three samples taken on each day from day 2 onwards tended to decline markedly in all of the Hoe 766-treated animals, an effect not seen in Gn-RF or 0.9% NaCl-treated controls.

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LH- and FSH Response to Long-Term Application of LH-RH Analogue in Normal Males

Cited by 34 publications

References 0 publications

Daily and Alternate‐day Treatment with an LHRH Analog in the Therapy of Idiopathic Hypogonadotropic Hypogonadism

Daily and Alternate‐day Treatment with an LHRH Analog in the Therapy of Idiopathic Hypogonadotropic Hypogonadism

LH‐RH Agonists and Antagonists

Repetitive Treatment With Gonadotrophin Releasing Factor or a Long-Acting Analogue Upon Gonadotrophin Secretion in the Ferret

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