LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development

Byrd, Kevin M.; Lough, Kendall J.; Patel, Jeet H.; Descovich, Carlos Patiño; Curtis, Thomas A.; Williams, Scott

doi:10.1242/dev.136010

Cited by 23 publications

(44 citation statements)

References 83 publications

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“…These cues may help to adapt spindle orientation to specific tissue requirements, for instance to induce perpendicular divisions and thereby epithelial multi-layering2. It will be interesting to test how the balance between competing cues is regulated, in particular in tissues in which LGN displays distinct localizations corresponding to differently oriented divisions46.…”

Section: Discussionmentioning

confidence: 99%

Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

et al. 2017

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Both cell–cell adhesion and oriented cell division play prominent roles in establishing tissue architecture, but it is unclear how they might be coordinated. Here, we demonstrate that the cell–cell adhesion protein E-cadherin functions as an instructive cue for cell division orientation. This is mediated by the evolutionarily conserved LGN/NuMA complex, which regulates cortical attachments of astral spindle microtubules. We show that LGN, which adopts a three-dimensional structure similar to cadherin-bound catenins, binds directly to the E-cadherin cytosolic tail and thereby localizes at cell–cell adhesions. On mitotic entry, NuMA is released from the nucleus and competes LGN from E-cadherin to locally form the LGN/NuMA complex. This mediates the stabilization of cortical associations of astral microtubules at cell–cell adhesions to orient the mitotic spindle. Our results show how E-cadherin instructs the assembly of the LGN/NuMA complex at cell–cell contacts, and define a mechanism that couples cell division orientation to intercellular adhesion.

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Section: Discussionmentioning

confidence: 99%

Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

et al. 2017

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“…Lineage tracing reveals that these micro-niche progenitor divisions fuel the coordinated growth of the individual onionskin- like layers that constitute the hair and its channel (Legue et al, 2010; Yang et al, 2017). Studies to date suggest that the asymmetric cell division prompted by WNT signaling in hair progenitors differs in mechanism from that seen in the embryonic epidermis (Byrd et al, 2016). …”

Section: Contribution and Dynamics Of Skin Stem Cells During Homeostamentioning

confidence: 99%

Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche

2017

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Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A high demand is placed on renewal and regeneration of the skin’s barrier in order to protect the body from infection and dehydration and to heal wounds. This review focuses on the epithelial stem cells of skin, where they come from, where they reside, and how they function in normal homeostasis and wound repair.

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“…An in-depth study of the CVP structure has not been conducted, nor have FOLP organs been examined. With genetic models, however, regulation of CVP number by the fibroblast growth factor pathway was shown (64), and roles for LGN, an adaptor protein in mitotic spindle orientation, in FILIFP morphogenesis were recently reported (65). …”

Section: Development and Tastementioning

confidence: 99%

Tongue and Taste Organ Biology and Function: Homeostasis Maintained by Hedgehog Signaling

Mistretta

Kumari

2017

Annu. Rev. Physiol.

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The tongue is an elaborate complex of heterogeneous tissues with taste organs of diverse embryonic origins. The lingual taste organs are papillae, composed of an epithelium that includes specialized taste buds, the basal lamina, and a lamina propria core with matrix molecules, fibroblasts, nerves, and vessels. Because taste organs are dynamic in cell biology and sensory function, homeostasis requires tight regulation in specific compartments or niches. Recently, the Hedgehog (Hh) pathway has emerged as an essential regulator that maintains lingual taste papillae, taste bud and progenitor cell proliferation and differentiation, and neurophysiological function. Activating or suppressing Hh signaling, with genetic models or pharmacological agents used in cancer treatments, disrupts taste papilla and taste bud integrity and can eliminate responses from taste nerves to chemical stimuli but not to touch or temperature. Understanding Hh regulation of taste organ homeostasis contributes knowledge about the basic biology underlying taste disruptions in patients treated with Hh pathway inhibitors.

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LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development

Cited by 23 publications

References 83 publications

Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche

Tongue and Taste Organ Biology and Function: Homeostasis Maintained by Hedgehog Signaling

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