LFA1 and ICAM1 are critical for fusion and spread of murine leukemia virus in vivo

Engels, Rebecca; Falk, Lydia A.; Albanese, Manuel; Keppler, Oliver T.; Sewald, Xaver

doi:10.1016/j.celrep.2021.110279

Cited by 1 publication

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References 60 publications

(90 reference statements)

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“…In the same study, the authors also showed that M5 protein blocked the parasite translocation of red blood cells by Plasmodium falciparum, irrespective of whether the strain is drug-susceptible or resistant (Bhalla et al 2015 ). Quite recently, ICAM-1/LFA-1 complex has been shown to play an important role in transmission of Murine Leukemia virus between leucocytes, thus, exploiting the host proteins involved in intercellular interactions and barrier function (Engels et al 2022 ). Collectively, it is evident that various microbes exploit host ICAM-1/LFA-1 in cell-to-cell transmission and infection, thus, providing a robust pathway to mitigate microbial infection and persistence.…”

Section: The Role Of Icam-1 In Other Diseasesmentioning

confidence: 99%

Targeting intercellular adhesion molecule-1 (ICAM-1) to reduce rhinovirus-induced acute exacerbations in chronic respiratory diseases

et al. 2022

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The chronic respiratory non-communicable diseases, asthma and chronic obstructive pulmonary disease (COPD) are among the leading causes of global mortality and morbidity. Individuals suffering from these diseases are particularly susceptible to respiratory infections caused by bacterial and/or viral pathogens, which frequently result in exacerbation of symptoms, lung function decline, frequent hospital emergency visits and increased socioeconomic burden. Human rhinoviruses (HRV) remain the major viral pathogen group implicated in exacerbations of both asthma and COPD. The rhinoviral entry into the host lung epithelium is facilitated primarily by the adhesion site (“receptor”) intercellular adhesion molecule-1 (ICAM-1), coincidentally expressed on the respiratory epithelium in these conditions. Multiple observations of increased airway ICAM-1 protein in asthmatics, smokers and smoking-related COPD have been recorded in the literature. However, the lack of robust therapies for COPD in particular has triggered a renewed interest in assessing receptor antagonism-based anti-viral strategies for treatment of intercurrent viral infections in those with pre-existing chronic lung diseases. Given the crucial role ICAM-1 plays in facilitating HRV adhesion and, thus, transmissibility to the host respiratory system, as well as the up-regulation of ICAM-1 by smoking, we summarize the role of HRV in smoking-induced COPD and especially highlight the role of ICAM-1 in epithelial viral adhesion and chronic lung disease progression. Further, the review also sheds light specifically on evolving precision therapeutic strategies in blocking ICAM-1 for preventing viral adhesion and exacerbations of COPD.

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Section: The Role Of Icam-1 In Other Diseasesmentioning

confidence: 99%

Targeting intercellular adhesion molecule-1 (ICAM-1) to reduce rhinovirus-induced acute exacerbations in chronic respiratory diseases

et al. 2022

View full text Add to dashboard Cite

show abstract

LFA1 and ICAM1 are critical for fusion and spread of murine leukemia virus in vivo

Abstract: Highlights d LFA1 and ICAM1 are important for cell-contact-dependent spread of MLV in vivo d LFA1 on target cells is critical for MLV cisand trans-infection d ICAM1 on donor cells is critical for MLV cis-infection d MLV fusion is not a limiting step to establish infection in vivo

Cited by 1 publication

References 60 publications

Targeting intercellular adhesion molecule-1 (ICAM-1) to reduce rhinovirus-induced acute exacerbations in chronic respiratory diseases

Targeting intercellular adhesion molecule-1 (ICAM-1) to reduce rhinovirus-induced acute exacerbations in chronic respiratory diseases

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