Leydig cell hyperplasia

Naughton, Cathy K.; Nadler, Robert B.; Basler, Joseph W.; Humphrey, Peter A.

doi:10.1046/j.1464-410x.1998.00503.x

Cited by 48 publications

(33 citation statements)

References 19 publications

(29 reference statements)

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“…A Sertoli cell tumor was identified in a testis simultaneously affected by LCT; the patient, who also received RPLND, was disease-free 68 months later. Leydig cell hyperplasia [7] and tumors associated to congenital adrenal hyperplasia [8] were ruled out in the patient with bilateral synchronous tumor.…”

Section: Resultsmentioning

confidence: 99%

Lessons from 52 Patients with Leydig Cell Tumor of the Testis: The GUONE (North-Eastern Uro-Oncological Group, Italy) Experience

Tonno

Tavolini

Belmonte³

et al. 2009

Urol Int

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Introduction: The goal of the study was to define treatment rules for the uncommon, rarely (10%) malignant and chemorefractory Leydig cell tumors (LCT) of the testis. Methods: The main clinical data of patients treated in centers affiliated to the GUONE (North-Eastern Uro-Oncological Group, Italy) were reviewed. We considered 52 patients (54 tumors, 2 bilateral) whose ages ranged from 13 to 70 years (mean 36). Of the treatments performed, 52 were orchiectomies and 2 were enucleations (unfavorable pathology in only 2 tumors). There were 5 lymphadenectomies (retroperitoneal lymph node dissections): 2 for suspected stage II disease and 1 each for unfavorable pathology, bilateral disease and associated Sertoli tumor (pathology: pN0 in all cases). The length of follow-up ranged from 15 to 249 months (mean 81). Results: There was no relapse in 51 patients and 1 died as a result of metastatic disease (orchiectomy at the age of 70; unremarkable pathology). Conclusions: Malignant LCT seems to be, in our experience, less frequent than previously reported. Age and pathology are useful prognostic factors, but their predictive value should never be considered absolute. Enucleation seems justified in young patients with favorable pathology. In clinical stage I LCT, retroperitoneal lymph node dissection should be offered to older patients and/or to patients with unfavorable pathology. A prolonged follow-up is mandatory.

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Section: Resultsmentioning

confidence: 99%

Lessons from 52 Patients with Leydig Cell Tumor of the Testis: The GUONE (North-Eastern Uro-Oncological Group, Italy) Experience

Tonno

Tavolini

Belmonte³

et al. 2009

Urol Int

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“…6 The data in the present study provides evidence that the scarcity of RCs may be a characteristic feature of immature adult LCs, this hypothesis being in concert with previous studies of hyperplastic LCs in infertile patients and men with Klinefelter syndrome. [28][29][30][31] In this study we re-investigated a previously reported finding that the number of RCs in undescended testes may be significantly greater than in normally descended testes. 15 We have confirmed a high number of RC-containing LCs in patients with a history of undescended testes, and revealed an interesting pattern of an increasing proportion of the RC-containing cells with the more cranial testis position and with significantly greater abundance of RCs in intra-abdominal testes.…”

Section: Discussionmentioning

confidence: 99%

Leydig cell clustering and Reinke crystal distribution in relation to hormonal function in adult patients with testicular dysgenesis syndrome (TDS) including cryptorchidism

Soerensen¹,

Johannsen²,

Skakkebæk³

et al. 2017

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oBjEcTIVE: Testicular dysgenesis syndrome (TDs) comprises testicular germ cell cancer, cryptorchidism and some cases of male infertility and hypospadias, which can be linked to impairment of intrauterine gonadal development. Among histological signs of TDs, large leydig cell (lc) clusters (micronodules) are frequently present. This study aimed to investigate possible associations of lc micronodules with the presence of reinke crystals and hormonal function of lcs, the latter primarily reflected by serum concentrations of luteinising hormone (lh) and testosterone, in patients with TDs. DEsIgn: A retrospective study of 101 andrological patients with TDs (infertility with and without a history of cryptorchidism or presence of germ cell neoplasia in situ) and 20 controls with normal testis histology and lc-function. Archived testicular biopsies were re-evaluated for the presence of lc micronodules and reinke crystals and the findings were correlated with testis size and serum concentrations of lh, follicle-stimulating hormone (Fsh), testosterone, inhibin B, estradiol and sex hormone binding globulin (shBg). rEsulTs: TDs patients with bilateral lc micronodules had significantly lower concentrations of lh, Fsh and inhibin B, a lower testosterone/lh-ratio and smaller testis sizes compared to TDs-patients lacking this feature. presence of lc micronodules was correlated with a lower number of reinke crystals, while cryptorchid testes had a significantly higher number of crystals than normally descended TDs testes. conclusIon: lc micronodules appear to be a compensatory mechanism caused by androgenic failure and are presumably driven by high concentrations of lh. A relative paucity of reinke crystals in lcs within micronodules in normally descended TDs testes may be a feature of recently renewed immature leydig cells. The increased number of reinke crystals in lcs in testes that were either undescended at birth or are persistently undescended could indicate an impairment of lc renewal in cryptorchidism.

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“…The exposure of EDCs can cause disturbing negative feedback mechanism of hypothalamic-pituitary-adrenal (HPA) axis, resulting an adverse effect of hormonal balance including the excessive production of luteinizing hormone (LH) that results Leydig cell hyperplasia. If the exposure is persistence and within the critical period, the change of Leydig cells can cause of severe form of hyperplasia ranging from dysplasia to malignancy [20]. Mostly, EDCs was designed have longer half-life for industrial benefit, it will unfortunately give long-term effect on disturbing negative feedback mechanism [21].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Early Mosquito Insecticides Exposure on Spraque Dawley Rat Testis: A Histopathological Feature Towards Malignancy?

Winarni

Aziman

Andar

et al. 2017

IOP Conf. Ser.: Earth Environ. Sci.

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Abstract. The incidence of health problems associated with endocrine-disruption have increased. Many studies suggesting that endocrine disruptor chemicals (EDC) do contribute to cancer through estrogenrelated receptors. Many chemicals have EDCs properties including insecticides. Early life exposure to EDCs can increased the risk of testicular cancer have been reported in the last decade. This study was aimed to determine the effect of insecticides exposure on histopathological tumor cell development of germ and Leydig cell. True experiment research design with posttest only control group design was applied. Sprague Dawley (SD) rat (n = 25) were randomly divided into 5 groups (control group, 25 mg β estradiol 3-benzoate, spiral mosquito coil repellent, 3 ml of liquid mosquito repellent, and 4 ml of liquid mosquito repellent). The exposure were administered for 20 days started at aged 3 days. At the age of 100 days (older adult), testis was stained using Hematoxyllin Eosin (HE) and histological features predicting malignancy were observed. The number of tumor cell development in both testicular germ cells and Leydig cells significantly increased in all treated group compared to those of control and the changes towards malignancy were also observed in all treated group. Exposure to mosquito insecticides causes significant changes in testicular germ and Leydig cell histological features that leads to malignancy.

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Leydig cell hyperplasia

Cited by 48 publications

References 19 publications

Lessons from 52 Patients with Leydig Cell Tumor of the Testis: The GUONE (North-Eastern Uro-Oncological Group, Italy) Experience

Lessons from 52 Patients with Leydig Cell Tumor of the Testis: The GUONE (North-Eastern Uro-Oncological Group, Italy) Experience

Leydig cell clustering and Reinke crystal distribution in relation to hormonal function in adult patients with testicular dysgenesis syndrome (TDS) including cryptorchidism

The Effect of Early Mosquito Insecticides Exposure on Spraque Dawley Rat Testis: A Histopathological Feature Towards Malignancy?

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