Lewis^xand α2,3-Sialyl Glycans and Their Receptors TAG-1, Contactin, and L1 Mediate CD24-Dependent Neurite Outgrowth

Abstract

Although carbohydrates have been implicated in cell interactions

Lewis X-carrying N-Glycans Regulate the Proliferation of Mouse Embryonic Neural Stem Cells via the Notch Signaling Pathway

“…It has been reported that NSCs treated with an organic solvent to wash out cell surface glycolipids have strong immunoreactivity with anti-Lewis X antibody (41), indicating that this glycotope is carried mainly by glycoproteins and/or proteoglycans rather than glycolipids. To date, phosphacan, CD24, integrin, L1-CAM, Thy-1, LAMP-1, and TNC have been identified as Lewis X-carrying proteins (36,38,(42)(43)(44)(45). Here, we demonstrated that LAMP-1 and TNC are major Lewis X carriers in NSCs (Fig.…”

The CASPR2 cell adhesion molecule functions as a tumor suppressor gene in glioma

“…Extracellularly, CASPR2 binds to contactin 2 (TAG-1), a neural recognition protein of the immunoglobulin cell adhesion molecule superfamily (Poliak et al, 2003). The CASPR2-contactin 2 complex is involved in clustering of K þ channels in the juxtaparanodal region of the nodes of Ranvier (Poliak et al, 2003) and in neurite outgrowth (Lieberoth et al, 2009). Germline genetic alterations in the CASPR2 gene have been found in several neurological and psychiatric diseases, including recessive symptomatic focal epilepsy and autism (Strauss et al, 2006;Bakkaloglu et al, 2008;Jackman et al, 2009), combined schizophrenia and epilepsy (Friedman et al, 2008) and Gilles de la Tourette's syndrome with obsessive-compulsive disorder (Verkerk et al, 2003).…”

CD24: from A to Z

“…All of these ligands mediate CD24-induced inhibition of neural growth. [17][18][19] In hematopoietic cells, CD24 is known to bind to molecules exhibiting danger-associated molecular patterns (DAMPs). Additionally, CD24, DAMPs and Siglec G (mouse) or Signlec 10 (human) form a trimolecular complex.…”