Lewis base and l-proline co-catalyzed Baylis–Hillman reaction of arylaldehydes with methyl vinyl ketone

One-pot easy conversion of Baylis-Hillman adducts into arylpyrazoles under ultrasound irradiation

“…24 To convert these products to the related 1,5-diarylpyrazoles under ultrasound condition (45 KHz), the reaction of Baylis-Hillman adduct (1a), phenylhydrazine hydrochloride in 1,2-dicloroethane was used (Scheme 1). This reaction was examined at various temperatures.…”

Methanolic trimethylamine mediated Baylis-Hillman reaction

“…IR spectra were recorded on a Jasco-FT-IR model 5300 spectrometer using liquid samples as neat liquids and solid samples as KBr plates. 1 H NMR (200 MHz) and 13 C NMR (50 MHz) spectra were recorded in deuterochloroform (CDCl 3 ) on a…”

Density Functional Study of Proline‐Catalyzed Intramolecular Baylis–Hillman Reactions

“…Only a few reports have discussed the mechanistic aspects of intramolecular B-H reactions. [5a, 18] Recently Hong and co-workers [5a] reported the prolinecatalyzed enantioselective intramolecular B-H reaction of hept-2-enedial, based on the intermolecular version previously studied by Shi et al, [20] as affording medium-to-high chemical yields and low optical selectivities. In the presence of imidazole as co-catalyst, the enantioselectivity of the reaction improves considerably and an inverted absolute configuration is observed.…”