Abstract:The palladium-catalysed Suzuki-Miyaura cross-coupling (SMC) reaction of organohalides and organoborons is a reliable method for carbon-carbon bond formation. This reaction involves a base-mediated transmetalation process, but the presence of a base also promotes competitive protodeborylation, which reduces the efficiency. Herein, we established a SMC reaction via Lewis acid-mediated transmetalation of an organopalladium(II) intermediate with organoborons. Experimental and theoretical investigations indicate th… Show more
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