Lewis acid-mediated cross-coupling reaction of 7-azaindoles and aldehydes: Cytotoxic evaluation of C3-linked bis-7-azaindoles

Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells

“…Alteration of metabolism and induction of apoptosis and autophagy have been regarded as an approach to combat metastatic cancer and inhibit cancer cell proliferation and survival. Various synthetic compounds exhibit potential anticancer activity against different types of human cancers [ 24 , 26 , 42 , 43 , 44 , 45 ]. The present study explored the anticancer potential of SH-859 in 786-O human kidney cancer cells.…”

Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)

“…Plant secondary metabolites are a diverse range of biologically active molecules having multiple pharmacological actions like antimicrobial, stimulant, analgesic, anthelmintic, anticoagulant, antiacne, and antioxidant, among others (Debnath et al, 2012;Bhakta, 2012, 2013;Dey et al, 2012bDey et al, , 2014Karuna et al, 2018aKaruna et al, , 2018bKundu et al, 2019). Different synthetic compounds show potential biological activity in vitro as well as in vivo ( Jeon et al, 2017;Jeong et al, 2017a, b;Kim et al, 2018;Lee et al, 2018Lee et al, , 2019Richa et al, 2019;Tae et al, 2018), and various formulations of existing drugs are also developed to increase the safety profile (Gorain et al, 2014;Karmakar et al, 2015;Maity et al, 2016). In spite of this technological development, humans from almost every culture are efficiently employing the plant-derived compounds for the anticipation and management of multiple health disorders for many centuries (Dey et al, 2012a, c).…”

I2/CAN as a Mild and Efficient Reagent for Oxidative Csp3‐Csp2 Cleavage of 3,3′‐Bis‐7‐azaindolylmethane: A Rapid One‐Pot Access to 3‐Formyl and 3‐Iodo‐7‐azaindoles

“…[2,3] For example, compounds I-VI functionalized at the C-3, and C-5 positions of 7-azaindole are the most prominent for bioactivity are shown in Figure 1. [4] 7-Azaindole-3-carboxaldehyde 3 is a well-known synthon for the synthesis of natural products and drugs. [5] The synthesis of indole-3-carboxaldehyde and 7-azaindole-3-carboxaldehyde is reported including Vilsmeier-Haack formylation, [6] I 2 catalyzed CÀ N cleavage, [7] CÀ C cleavage, [8] electrochemical decarboxylation, [9] oxidative decarboxylation/NÀ O cleavage, [10] Rieche formylation, [11] CAN oxidation, [12] and Duff reaction.…”

“…Furthermore, the 7‐azaindole skeleton has both H‐acceptor and H‐donor property that enhances the pharmacological property in anti‐inflammatory, hypotensive, analgesic, anti‐HIV, and anticancer properties [2,3] . For example, compounds I–VI functionalized at the C‐3, and C‐5 positions of 7‐azaindole are the most prominent for bioactivity are shown in Figure 1 [4] …”