Lewis Acid Catalyzed [3+3] Annulation/Aldol Condensation in Water: One Pot Synthesis of (E,E)‐4,6‐Bis(styryl)‐Pyrimidines

Abstract

An efficient and facile one pot synthesis of (E,E)‐4,6‐bis(styryl)‐pyrimidines has been developed. It involves one pot two step reactions in environmentally benign solvent water, where first step involves pyrimidine ring formation from acetylacetone and urea via [3+3] annulation, followed by aldol condensation with differently substituted aromatic aldehyde to give desired (E,E)‐4,6‐bis(styryl)‐pyrimidines in moderate to good yields.

Copper(ii) nanodots stabilized on Cassia fistula galactomannan: preparation and catalytic application towards fast solvent-free Biginelli reactions

“…With these details, and in continuation of our research efforts in the field of development of new methods in organic synthesis, 28,29 we have been interested to extend our research work in the synthesis and application of biopolymer-based metal catalysts for multicomponent reactions. We herein report the preparation of biopolymer-supported Cu( ii ) nanodots (Cu( ii )NDs@CFG) as a heterogeneous catalyst for the multicomponent Biginelli reaction through the coordination of copper( ii ) to the naturally-occurring Cassia fistula galactomannan biopolymer.…”