Levothyroxine Replacement Improves Oxidative Status in Primary Hypothyroidism

Masullo, Laís Farias; Magalhães, Rejane Araújo; Lemes, Romélia Pinheiro Gonçalves; Filho, Tarcísio Paulo de Almeida; Castro, Marilena Facundo de; Filho, Pedro Aurio Maia; Cunha, Tainá Osterno Vasconcelos; Quidute, Ana Rosa Pinto; Fontenele, Eveline Gadelha Pereira; Sun, Guang; Martins, Manoel Ricardo Alves

doi:10.3389/fendo.2018.00655

Cited by 20 publications

(12 citation statements)

References 30 publications

(43 reference statements)

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“…Decreased oxidative stress has been reported after levothyroxine treatment in patients with hypothyroidism. Masullo et al [ 26 ] reported significantly decreased levels of malonaldehyde and increased catalase activity in female hypothyroid patients. Ates et al [ 27 ] found decreased oxidant status and increases antioxidant status following the 6 months of levothyroxine replacement in hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

Necroptosis mediated by receptor interacting protein kinase 3 as critical player in experimental congenital hypothyroidism related neuronal damage

Duman¹

2021

North Clin Istanbul

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OBJECTIVE: Congenital hypothyroidism (CH) is literally described as congenital thyroid hormone imperfection. The primary objective of this research was to reveal the possible relation between receptor-acting protein kinase 3 (RIPK3) activity and neuronal damages in rat pups with CH. In addition, we evaluated the favorable impacts of 3.6-dibromo-α-([phenylamino] methyl)-9H-carbazole-9-ethanol (P7C3) reducing RIPK3 activity. METHODS: Adult rats were accordingly assigned into four groups: Group 1, which is called congenital hypothyroid; Group 2, which is called congenital hypothyroid administered P7C3; Group 3, called CH administered P7C3 and L-thyroxine; and Group 4, control group. RIPK3 level in plasma concentration and its expression in tissue was determined in all groups. RESULTS: Increased RIPK3 expressions were detected as high in the CH group when it is compared to the control group. Furthermore; the expressions in neuronal cytoplasm were found similar among Groups II and III. RIPK3 expressions in those two groups were relatively higher than in the control group. Most reacted parts of the brain were especially Purkinje cells in the cerebellum. CONCLUSION: It is concluded that there is excellent parallelism among damaged neurons and high RIPK3 activity in CH pathogenesis. P7C3 compounds may have a safeguarding impact on CH due to decreasing RIPK3 activity.

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Section: Discussionmentioning

confidence: 99%

Necroptosis mediated by receptor interacting protein kinase 3 as critical player in experimental congenital hypothyroidism related neuronal damage

Duman¹

2021

North Clin Istanbul

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“…Oxidative stress occurs when there is an imbalance between pro-oxidants and antioxidants, which occurs when antioxidant defenses cannot neutralize oxidants [28]. Excess thyroid hormones increases energy demand and mitochondrial activity that surge the ROS production [29].…”

Section: Discussionmentioning

confidence: 99%

Octreotide (somatostatin analog) attenuates cardiac ischemia/reperfusion injury via activating nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway in rat model of hyperthyroidism

2020

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Background Hyperthyroidism is known to increase the risk of ischemic heart diseases. Octreotide has been reported to attenuate ischemia/reperfusion (I/R) injury. Whether it is useful when ischemic heart disease is accompanied with co-morbidities like hyperthyroidism needs more clarifying. So, this study aimed to explore the effect of octreotide on cardiac I/R injury in hyperthyroid rats and to clarify if Nrf2 activation is involved in this effect. Forty adult female Wistar rats were subdivided into control (euthyroid) (n = 10) and hyperthyroid (n = 30) groups. Rats in hyperthyroid group received l-thyroxine (12 mg/L) in drinking water for 35 days, then were randomly divided into three equal subgroups (n = 10): hyperthyroid control positive group, hyperthyroid octreotide treated group, and hyperthyroid octreotide + Nrf2 inhibitor (brusatol) treated group. Isolated hearts were submitted to I/R and evaluated for cardiac hemodynamics and infarct size. Serum T3 and T4, coronary efflux lactate dehydrogenase (LDH) and creatine kinase-myoglobin binding (CK-MB) and cardiac tissue malondialdehyde (MDA) were estimated. Nrf2- regulated gene expressions of HO-1, SOD, GPx, and catalase were assessed. Results Octreotide administration to hyperthyroid rats improved baseline and post-ischemic recovery of cardiac hemodynamics, decreased the high coronary efflux LDH and CK-MB and tissue MDA, reduced infarction size, and upregulated the decreased antioxidative enzymes HO-1, SOD, GPx, and catalase mRNA expressions in the hyperthyroid I/R rat hearts. The Nrf2 inhibitor brusatol reversed the cardioprotective effect of octreotide in hyperthyroid I/R rat hearts. Conclusion Octreotide can reduce oxidative stress to effectively alleviate I/R injury in the hyperthyroid rat hearts through upregulation of Nrf2-dependent antioxidative signaling pathways.

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“…In addition, hypothyroidism is associated with depression in a bi-directional manner [32], and depression is a risk factor in itself for dementia [33]. Furthermore, an improvement of oxidative status in women with hypothyroidism is shown [34]. Results from animal models show different possible mechanisms, e.g., improvement in hippocampus function [35], and possibly also an augmentation of cholinergic activity [36].…”

Section: Discussionmentioning

confidence: 99%

Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism

et al. 2018

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Background and Objective The possible adverse or positive effects of levothyroxine treatment among patients with atrial fibrillation have been debated. Atrial fibrillation, levothyroxine treatment, and dementia are common among older adults, yet little is known about the effects of levothyroxine on the development of dementia. Methods The study population included all adults ( n = 12,057) aged ≥ 45 years with a diagnosis of atrial fibrillation at 75 primary care centers in Sweden during 2001–2007 without an earlier recorded dementia diagnosis. Patients with a diagnosis of hypothyroidism and levothyroxine prescription ( n = 756; 180 men and 576 women), or with a prescription without this diagnosis ( n = 415, 100 men and 315 women), were compared to patients without a diagnosis and prescription ( n = 10,886). Cox regression was performed, with hazard ratios and 95% confidence intervals, with outcome defined as dementia of all causes until 31 December, 2010. Results During a mean 5.7 years (standard deviation 2.4 years) of follow-up, a total of 749 patients with atrial fibrillation (6.2%) were diagnosed with dementia. Women with hypothyroidism and a levothyroxine prescription showed lower hazard ratios (0.61; 0.41–0.90) in adjusted Cox regression models (age, socioeconomic factors, co-morbidity, and warfarin treatment). Levothyroxine prescription without hypothyroidism was non-significant. Conclusions We found that women with atrial fibrillation with levothyroxine treatment and hypothyroidism have a lower risk of incident dementia than women with atrial fibrillation without levothyroxine treatment and no hypothyroidism. The results should be confirmed in larger studies. Electronic supplementary material The online version of this article (10.1007/s40261-018-0740-3) contains supplementary material, which is available to authorized users.

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Levothyroxine Replacement Improves Oxidative Status in Primary Hypothyroidism

Cited by 20 publications

References 30 publications

Necroptosis mediated by receptor interacting protein kinase 3 as critical player in experimental congenital hypothyroidism related neuronal damage

Necroptosis mediated by receptor interacting protein kinase 3 as critical player in experimental congenital hypothyroidism related neuronal damage

Octreotide (somatostatin analog) attenuates cardiac ischemia/reperfusion injury via activating nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway in rat model of hyperthyroidism

Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism

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