2010
DOI: 10.2515/therapie/2010070
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Levothyroxine Induced Eczematiform Skin Eruption and Generalized Pruritus: a Case Report

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Cited by 5 publications
(5 citation statements)
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“…In that case the dog apparently suffered an idiosyncratic reaction to one of the inactive ingredients of the thyroid supplement rather than the hormone itself. Despite numerous discussions of such a reaction on professional medical sites, the human literature contains a limited number of published cases . Interestingly, most human cases appear to be “immediate” reactions (i.e.…”
Section: Discussionmentioning
confidence: 57%
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“…In that case the dog apparently suffered an idiosyncratic reaction to one of the inactive ingredients of the thyroid supplement rather than the hormone itself. Despite numerous discussions of such a reaction on professional medical sites, the human literature contains a limited number of published cases . Interestingly, most human cases appear to be “immediate” reactions (i.e.…”
Section: Discussionmentioning
confidence: 57%
“…Adult‐onset canine hypothyroidism is an immune‐mediated disease for which some genetic predispositions, including MHC II, have been suggested . Reported cases of allergic reactions to thyroid supplements in human medicine have included no, or limited, investigations of the specific target ingredient or its exact pathogenesis …”
Section: Discussionmentioning
confidence: 99%
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“…In cases of adverse skin reactions, patch tests were all positive, suggesting the involvement of delayed type hypersensitivity (DTH). [3][4][5] As a biological substance, levothyroxine cannot be recognized by the immune system as antigen. Nevertheless, lymphocytes of patients who had taken levothyroxine were indeed sensitized to the drug.…”
Section: Discussion and Reviewmentioning
confidence: 99%
“…Only a few skin lesions have been reported to be induced by levothyroxine as consequences of anaphylactic reactions, including pruritic rashes, eczematiform skin eruptions, and lichenoid eruptions. [3][4][5] Cutaneous lichenoid or lichen-planus-like eruptions may be induced by ingestion, contact or inhalation of a variety of drugs and chemicals. It is similar to lichen planus clinically and pathologically, with purple-red papules, obvious scales and eczematous change.…”
mentioning
confidence: 99%