Levosimendan Reduces Lung Injury in a Canine Model of Cardiopulmonary Bypass

Abstract

Background and ObjectivesTo explore the lung-protective effect of levosimendan (LS) during cardiopulmonary bypass in a canine model by determining the wet/dry weight (W/D) ratio of lung tissue, malonaldehyde (MDA) and superoxide dismutase (SOD) concentrations, and performing a histological evaluation.Materials and MethodsThirty-two canines were divided randomly into four groups and underwent a routine aortic cross-clamping cardiopulmonary bypass procedure for 1 h, followed by recovery for 2 h. Animals were handled as follows: group C (means control group), no special treatment after aortic cross clamping; group P (means pulmonary artery perfusion group), pulmonary artery perfusion with cold oxygenated blood after aortic cross clamping; group LSIV (means intravenous injection of LS group), intravenous injection of LS (65 µg/kg) before thoracotomy, and the rest of the procedure was identical to the control group; group LPS (means pulmonary perfusion with LS group), pulmonary perfusion with cold oxygenated blood combined with LS (65 µg/kg) after aortic cross clamping. Lung tissues were removed and subjected to evaluation of pathological alterations, W/D ratio and MDA and SOD concentrations.ResultsIn group C, the W/D ratio and MDA concentration were higher, while the SOD concentrations were lower (p<0.05). Compared with groups P and LSIV, the MDA concentration was lower in group LPS, while that of SOD was higher (p<0.05); Light and electron microscopy indicated that LS intervention reduced impairment of lung tissues.ConclusionOur findings suggest that LS plays an important role in protecting lung tissues.

The Perioperative Use of Levosimendan as a Means of Optimizing the Surgical Outcome in Patients with Severe Heart Insufficiency Undergoing Cardiac Surgery

“…The administration of levosimendan exhibited a protective effect on lung function by reducing the duration of postoperative ventilation ( p = 0.007), although there was no significant difference in ICU stay ( p = 0.664) or in total hospital stay ( p = 0.405) between the two groups. Our findings align with experimental evidence supporting the lung-protective properties of levosimendan [ 15 , 16 ]. Studies by Landoni et al [ 1 ] and Lim et al [ 17 ] demonstrated a noteworthy reduction in hospital stay among patients treated with levosimendan.…”

The Relationship Between Heart Rate and Left Ventricular Isovolumic Relaxation During Normoxia and Hypoxia-Asphyxia in Newborn Piglets

“…Diastolic dysfunction is a hemodynamic hallmark of heart failure. Many reports attempt to demonstrate the importance of early recognition of cardiac dysfunction by using echocardiography or other methods (Feng et al, 2016; Jang et al, 2016). While systolic function could be evaluated using echocardiography (such as ejection fraction, shortening fraction), the assessment of diastolic dysfunction (e.g., IVR time) by non-invasive method is challenging (Nagueh et al, 2009; Savage et al, 2010).…”

Activated Α7nachr Improves Postoperative Cognitive Dysfunction and Intestinal Injury Induced by Cardiopulmonary Bypass in Rats: Inhibition of the Proinflammatory Response Through the Th17 Immune Response

“…Despite the continuous improvement in different cardiac surgical techniques, the incidence of postoperative complications remains high. Such complications, which include POCD [19], acute lung injury [20], kidney injury [21], and intestinal injury [22], have become an important obstacle to the development of cardiac surgery. In this study, 6% hydroxyethyl starch was injected into Sprague-Dawley rats through the right venous drainage and right femoral artery fusion to establish a CPB model.…”