Levonorgestrel‐releasing intrauterine device in the treatment of menorrhagia

Andersson, JK; Rybo, Göran

doi:10.1016/0020-7292(91)90855-y

Cited by 88 publications

(124 citation statements)

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“…Therefore, long-term evaluations of our study groups are necessary. Bleeding and spotting disorders associated with the LNG-IUS are common during the first few months and in most cases are resolved after 3-6 months of use (18). In the literature, the reported removal rate of the LNG-IUS due to bleeding problems is low (19,20).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of quality of life and cost-effectiveness of definitive surgery and the levonorgestrel intrauterine system as treatment options for heavy menstrual bleeding

Adıgüzel¹,

Seyfettinoğlu²,

Satar³

et al. 2017

Turk J Med Sci

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A total of 104 patients aged 20-55 years, with complaints of regular HMB, were enrolled in the study from January 2013 to June 2015. Ninety-eight women completed the study. The inclusion criteria were the presence of HMB, reproductive age, a completed family, failure of appropriate first-line oral medical therapy, normal Pap smear, no pelvic pathology on ultrasound, normal endometrial biopsy, and pictorial blood loss assessment chart scores of ≥100 (average of two consecutive cycles). The exclusion criteria were previous endometrial resection/ablation, any uterine pathology on scans or hysteroscopy, incompletely investigated abnormal uterine bleeding, and postmenopausal bleeding. The local ethics committee approved this study.Background/aim: This study aimed to compare the levonorgestrel intrauterine system (LNG-IUS) with abdominal hysterectomy (TAH) and total laparoscopic hysterectomy (TLH) as first-line treatments for heavy menstrual bleeding (HMB). Materials and methods:Ninety-eight patients aged 20-55 years who complained of regular heavy menstrual bleeding were enrolled in the study. The TAH group included 29 patients, the LNG-IUS group included 34, and the TLH group included 35. These groups were compared in terms of quality of life and the cost-effectiveness of the selected methods. Quality of life was assessed using the 36-Item Short Form (SF-36), and cost-effectiveness was assessed according to the current cost of each approach.

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Section: Discussionmentioning

confidence: 99%

Evaluation of quality of life and cost-effectiveness of definitive surgery and the levonorgestrel intrauterine system as treatment options for heavy menstrual bleeding

Adıgüzel¹,

Seyfettinoğlu²,

Satar³

et al. 2017

Turk J Med Sci

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“…Most of the studies published so far have been short term of between three months to twelve months 5 . Lahteenmaki et al 4 carried out an open randomised study in women waiting for hysterectomy and offered them LNG-IUS or continuation of medical treatment. At a six -month interval, 64.3% continued with it; the continuation rate dropped to 48% after three years.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported improvement in bleeding patterns between three months and a year of use 4 . The long term effectiveness in the management of menorrhagia and whether it is a worthwhile alternative to surgery has not been assessed.…”

Section: Introductionmentioning

confidence: 93%

Can the levonorgestrel intrauterine system replace surgical treatment for the management of menorrhagia?

Nagrani¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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“…The IUD group included nine women, 32 to 49 years old (mean age, 38 years), who used a levonorgestrel-containing IUD (Mirena; Schering, Germany) which releases 20 g levonorgestrel per 24 h and induces amenorrhea in 80 to 90% of the users 1 year after insertion (1). All women in the IUD group were amenorrheic.…”

Section: Methodsmentioning

confidence: 99%

Influence of Exogenous Reproductive Hormones on Specific Antibody Production in Genital Secretions after Vaginal Vaccination with Recombinant Cholera Toxin B Subunit in Humans

Wassén

Jertborn

2006

Clin Vaccine Immunol

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The objective of this study was to investigate the influence of exogenous reproductive hormones on the local and systemic production of specific immunoglobulin A (IgA) and IgG antibodies after vaginal vaccination with recombinant cholera toxin subunit B (CTB). Three groups of women using either progesterone-containing intrauterine devices (n ‫؍‬ 9), oral contraceptives (n ‫؍‬ 8), or no hormonal contraceptive methods (n ‫؍‬ 9) were vaginally immunized twice, 2 weeks apart. Cervical secretions, vaginal fluids, and serum were collected before and after vaccination.

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Levonorgestrel‐releasing intrauterine device in the treatment of menorrhagia

Cited by 88 publications

References 0 publications

Evaluation of quality of life and cost-effectiveness of definitive surgery and the levonorgestrel intrauterine system as treatment options for heavy menstrual bleeding

Evaluation of quality of life and cost-effectiveness of definitive surgery and the levonorgestrel intrauterine system as treatment options for heavy menstrual bleeding

Can the levonorgestrel intrauterine system replace surgical treatment for the management of menorrhagia?

Influence of Exogenous Reproductive Hormones on Specific Antibody Production in Genital Secretions after Vaginal Vaccination with Recombinant Cholera Toxin B Subunit in Humans

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