Levonorgestrel-releasing and copper-releasing (Nova T) IUDs during five years of use: A randomized comparative trial

Andersson, Kerstin; Odlind, Viveca; Rybo, Göran

doi:10.1016/0010-7824(94)90109-0

Cited by 461 publications

(373 citation statements)

References 18 publications

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“…Sivin reported a significantly higher expulsion rate over 7 years for the LNG-IUD in comparison with the copper T 380Ag (CuT 380Ag) (11.7% versus 8.4%). No difference in the expulsion rate for both IUD types was reported by Anderson et al [16]. In contrast to these data, we found a lower dislocation rate for the LNG-IUD 6 weeks after insertion (4% versus 11%, p 0.06) and a significantly lower number of dislocations over the entire observation period in the LNG-IUD group (18% versus 29%, p 0.05).…”

Section: Discussioncontrasting

confidence: 99%

Partial and complete expulsion of the Multiload 375 IUD and the levonorgestrel-releasing IUD after correct insertion

Merki‐Feld¹,

Schwarz²,

Imthurn³

et al. 2008

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: The contraceptive efficacy of intrauterine devices (IUD) is thought to relate to the position of the IUD in the uterine cavity. Several trials examined the number of copper IUD expulsions, but none evaluated the partial and complete expulsion rate of the levonorgestrelreleasing device (LNG-IUD).Study design: This retrospective cohort study compares the dislocation rate of the Multiload 375 IUD (ML 375) and the LNG-IUD in 214 women (107 subjects with each IUD). Transvaginal ultrasound was used to monitor the IUD position immediately after insertion, after 6 weeks, and later on at intervals of 6 months. The observation period included 3631 cycles.Results: We detected a significantly lower number of dislocations in LNG-IUD users. Previous expulsion was associated with a significantly higher risk for a re-expulsion in both IUD groups. Hypermenorrhea was not associated with an increased dislocation rate in LNG-IUD users. Conclusion: Expulsions are less likely to occur with the LNG-IUD, which might contribute to its contraceptive efficacy. #

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Section: Discussioncontrasting

confidence: 99%

Partial and complete expulsion of the Multiload 375 IUD and the levonorgestrel-releasing IUD after correct insertion

Merki‐Feld¹,

Schwarz²,

Imthurn³

et al. 2008

European Journal of Obstetrics & Gynecology and Reproductiv

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“…For many women, amenorrhea became a desirable effect of using a hormonal contraceptive. The first LNG 52 mg IUS introduced to the market reported a 1-year amenorrhea rate of 20% but lacked information about when amenorrhea occurred during the first year or who becomes amenorrheic [1,2]. The data for the 20% amenorrhea rate were obtained primarily from Contraception xx (2017) xxx -xxx Scandinavian multiparous women, 75% of whom had used intrauterine contraception previously [3].…”

Section: Introductionmentioning

confidence: 99%

Amenorrhea rates and predictors during 1 year of levonorgestrel 52 mg intrauterine system use

et al. 2018

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Objective: The objective was to evaluate amenorrhea patterns and predictors of amenorrhea during the first year after levonorgestrel 52 mg intrauterine system (IUS) placement. Study design: This cohort analysis includes 1714 nulliparous and parous women who received a Liletta® levonorgestrel 52 mg IUS in a multicenter trial to evaluate efficacy and safety for up to 8 years. Participants maintained a daily diary with bleeding information. We assessed bleeding patterns in 90-day intervals; amenorrhea was defined as no bleeding or spotting in the preceding 90 days. We employed multivariable regression to identify predictors of amenorrhea at 12 months. The predictor analysis only included women not using a levonorgestrel IUS in the month prior to study enrollment. Results: In the month before enrollment, 148 and 1566 women, respectively, had used and not used a levonorgestrel IUS. Prior users averaged 50±19 months of use before IUS placement; 38.4% of these women reported amenorrhea at 12 months. Amenorrhea rates for non-prior-users at 3, 6, 9 and 12 months were 0.2%, 9.1%, 17.2% and 16.9%, respectively. During the first 12 months, 29 (1.7%) women discontinued for bleeding irregularities; no women discontinued for amenorrhea. The only significant predictor of amenorrhea at 12 months was self-reported baseline duration of menstrual flow of fewer than 7 days vs. 7 or more days (18.2% vs. 5.2%, adjusted odds ratio 3.70 [1.69, 8.07]). We found no relationships between 12-month amenorrhea rates and age, parity, race, body mass index, baseline flow intensity or hormonal contraception use immediately prior to IUS placement. Conclusions: Amenorrhea rates during the first year of levonorgestrel 52 mg IUS use are similar at 9 and 12 months. Amenorrhea at 12 months is most common among women with shorter baseline duration of menstrual flow. Implications statement: This information provides more data for clinicians when counseling women about amenorrhea expectations, especially since women seeking a levonorgestrel 52 mg IUS for contraception are different than women desiring treatment for heavy menstrual bleeding. Amenorrhea at 12 months is most common among women with shorter baseline duration of menstrual flow.

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“…The 5-year continuation rate can be as low as 40% [26]. For the LNG-IUS (Mirena), removal rates for medical reasons of 35-40% at 5 years have been reported which included malposition and displacement of the LNG-IUS [27,28]. In the CHOICE study, continuation rates at 5 year were 51.7% for the LNG-IUS and 55.9% for the TCu380 IUD, respectively [29].…”

Section: Malpositioned and Displaced Iuds Cause Early Removalmentioning

confidence: 99%

Malposition and displacement of intrauterine devices–diagnosis, management and prevention

Wildemeersch¹,

Hasskamp²,

Goldstuck³

2016

Clin Obstet Gynecol Reprod Med

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Levonorgestrel-releasing and copper-releasing (Nova T) IUDs during five years of use: A randomized comparative trial

Cited by 461 publications

References 18 publications

Partial and complete expulsion of the Multiload 375 IUD and the levonorgestrel-releasing IUD after correct insertion

Partial and complete expulsion of the Multiload 375 IUD and the levonorgestrel-releasing IUD after correct insertion

Amenorrhea rates and predictors during 1 year of levonorgestrel 52 mg intrauterine system use

Malposition and displacement of intrauterine devices–diagnosis, management and prevention

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