Levofloxacin loaded clove oil nanoscale emulgel promotes wound healing in Pseudomonas aeruginosa biofilm infected burn wound in mice

Razdan, Karan; Kanta, Shashi; Chaudhary, Ekta; Kumari, Sudesh; Rahi, Deepak Kumar; Yadav, Ashok Kumar; Sinha, Vivek Ranjan

doi:10.1016/j.colsurfb.2022.113113

Cited by 10 publications

(5 citation statements)

References 34 publications

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“…The product was tested against mice and the wound closure state was observed on the 1st, 3rd, 7th, 10th, and 15th day. The results indicated a faster reduction in wound size and a complete wound closure after 15 days in comparison with the samples without the additive, which were not completely closed in that period [150].…”

Section: Other Polymer Wound Dressingsmentioning

confidence: 88%

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Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings

et al. 2023

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Wound care is a global health issue with a financial burden of up to US $96.8 billion annually in the USA alone. Chronic non-healing wounds which show delayed and incomplete healing are especially problematic. Although there are more than 3000 dressing types in the wound management market, new developments in more efficient wound dressings will require innovative approaches such as embedding antibacterial additives into wound-dressing materials. The lack of novel antibacterial agents and the misuse of current antibiotics have caused an increase in antimicrobial resistance (AMR) which is estimated to cause 10 million deaths by 2050 worldwide. These ongoing challenges clearly indicate an urgent need for developing new antibacterial additives in wound dressings targeting microbial pathogens. Natural products and their derivatives have long been a significant source of pharmaceuticals against AMR. Scrutinising the data of newly approved drugs has identified plants as one of the biggest and most important sources in the development of novel antibacterial drugs. Some of the plant-based antibacterial additives, such as essential oils and plant extracts, have been previously used in wound dressings; however, there is another source of plant-derived antibacterial additives, i.e., those produced by symbiotic endophytic fungi, that show great potential in wound dressing applications. Endophytes represent a novel, natural, and sustainable source of bioactive compounds for therapeutic applications, including as efficient antibacterial additives for chronic wound dressings. This review examines and appraises recent developments in bioactive wound dressings that incorporate natural products as antibacterial agents as well as advances in endophyte research that show great potential in treating chronic wounds.

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Section: Other Polymer Wound Dressingsmentioning

confidence: 88%

“…Emulgels and nanoemulgels have been used extensively with plant extracts and essential oils as an additive. Ocimum basilicum extracts [149], clove oil [150], rosemary oil [151], and piper betle oil [152] are some of these additives.…”

Section: Other Polymer Wound Dressingsmentioning

confidence: 99%

Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings

et al. 2023

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“…The first stage is the treatment without a dressing, the second is treatment with a dressing saturated by pharmacological ointment, and the last stage is the reconstruction of skin and the repair of scars [ 138 , 139 ]. The most popular formulae for microemulsion treatment in medicine and cosmetological practice are emulsified lotions, balsams, gels, ointments, aerosols and modern emulgels [ 140 , 141 ]. According to the last reports, the new innovative nanoemulgels are developed as a prolonged release drug system [ 142 ].…”

Section: Applications For Emulsions In Biotechnology and Biomedicinementioning

confidence: 99%

Nano- and Microemulsions in Biomedicine: From Theory to Practice

et al. 2023

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Nano- and microemulsions are colloidal systems that are widely used in various fields of biomedicine, including wound and burn healing, cosmetology, the development of antibacterial and antiviral drugs, oncology, etc. The stability of these systems is governed by the balance of molecular interactions between nanodomains. Microemulsions as a colloidal form play a special important role in stability. The microemulsion is the thermodynamically stable phase from oil, water, surfactant and co-surfactant which forms the surface of drops with very small surface energy. The last phenomena determines the shortage time of all fluid dispersions including nanoemulsions and emulgels. This review examines the theory and main methods of obtaining nano- and microemulsions, particularly focusing on the structure of microemulsions and methods for emulsion analysis. Additionally, we have analyzed the main preclinical and clinical studies in the field of wound healing and the use of emulsions in cancer therapy, emphasizing the prospects for further developments in this area.

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“…Levofloxacin (LEV) is a broad-spectrum antibiotic from the fluoroquinolone drug class that has been used in the treatment of burn wound infections. It offers a bactericidal effect via inhibition of bacterial DNA synthesis and further damage of DNA strands ( Podder and Sadiq, 2022 ; Razdan et al, 2023 ). LEV has been shown to provide a high antibacterial activity against S. aureus , P. aeruginosa , L. pneumophila , and salmonellae in vitro ( Smith et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Levofloxacin loaded poly (ethylene oxide)-chitosan/quercetin loaded poly (D,L-lactide-co-glycolide) core-shell electrospun nanofibers for burn wound healing

Monavari,

Sohrabi,

Motasadizadeh

et al. 2024

Front. Bioeng. Biotechnol.

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This study developed a new burn wound dressing based on core-shell nanofibers that co-deliver antibiotic and antioxidant drugs. For this purpose, poly(ethylene oxide) (PEO)-chitosan (CS)/poly(D,L-lactide-co-glycolide) (PLGA) core-shell nanofibers were fabricated through co-axial electrospinning technique. Antibiotic levofloxacin (LEV) and antioxidant quercetin (QS) were incorporated into the core and shell parts of PEO-CS/PLGA nanofibers, respectively. The drugs could bond to the polymer chains through hydrogen bonding, leading to their steady release for 168 h. An in vitro drug release study showed a burst effect followed by sustained release of LEV and QS from the nanofibers due to the Fickian diffusion. The NIH 3T3 fibroblast cell viability of the drug loaded core-shell nanofibers was comparable to that in the control (tissue culture polystyrene) implying biocompatibility of the nanofibers and their cell supportive role. However, there was no significant difference in cell viability between the drug loaded and drug free core-shell nanofibers. According to in vivo experiments, PEO-CS-LEV/PLGA-QS core-shell nanofibers could accelerate the healing process of a burn wound compared to a sterile gauze. Thanks to the synergistic therapeutic effect of LEV and QS, a significantly higher wound closure rate was recorded for the drug loaded core-shell nanofibrous dressing than the drug free nanofibers and control. Conclusively, PEO-CS-LEV/PLGA-QS core-shell nanofibers were shown to be a promising wound healing material that could drive the healing cascade through local co-delivery of LEV and QS to burn wounds.

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Levofloxacin loaded clove oil nanoscale emulgel promotes wound healing in Pseudomonas aeruginosa biofilm infected burn wound in mice

Cited by 10 publications

References 34 publications

Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings

Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings

Nano- and Microemulsions in Biomedicine: From Theory to Practice

Levofloxacin loaded poly (ethylene oxide)-chitosan/quercetin loaded poly (D,L-lactide-co-glycolide) core-shell electrospun nanofibers for burn wound healing

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