Levofloxacin-induced rhabdomyolysis: a case report

John, Febin; Oluronbi, Ruby; Pitchumoni, C. S.

doi:10.1186/s13256-016-1004-6

Cited by 11 publications

(10 citation statements)

References 8 publications

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“…Our results demonstrated significant rhabdomyolysis associations (from strongest to weakest) with daptomycin, cefditoren, cefaclor, erythromycin, norfloxacin, clarithromycin, meropenem, azithromycin, cefdinir, piperacillintazobactam, trimethoprim-sulfamethoxazole, linezolid, and ciprofloxacin. Our results confirmed previously known rhabdomyolysis associations with daptomycin, macrolides, trimethoprimsulfamethoxazole, linezolid, fluoroquinolones, and cefdinir [2][3][4][5][6][7][8][9][10][11][12][13][14]. Meropenem, cefditoren, cefaclor, and piperacillin-tazobactam were found to be associated with rhabdomyolysis, which were not reported in the literature.…”

Section: Discussionsupporting

confidence: 91%

“…There have been case reports linking the use of linezolid to serious cases of rhabdomyolysis [10,11]. Fluoroquinolones have also been shown to be associated with rhabdomyolysis in case reports when fluoroquinolones were used alone or in combination with statins [12,13]. Rhabdomyolysis is listed as an adverse drug reaction (ADR) of cefdinir in its United States Food and Drug Administration (FDA) label [14].…”

Section: Ivyspringmentioning

confidence: 99%

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Rhabdomyolysis Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)

Teng¹,

Baus²,

Wilson³

et al. 2019

Int. J. Med. Sci.

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Introduction: Daptomycin, macrolides, trimethoprim-sulfamethoxazole, linezolid, fluoroquinolones, and cefdinir are known to be associated with rhabdomyolysis. Other antibiotics may also lead to rhabdomyolysis, but no study has systemically compared rhabdomyolysis associations for many available antibiotics. Objectives: The objective of this study was to evaluate the association between rhabdomyolysis and many available antibiotics using the FDA Adverse Event Report System (FAERS). Methods: FAERS reports from January 1, 2004 to December 31, 2017 were included in the study. The Medical Dictionary for Regulatory Activities (MedDRA) was used to identify rhabdomyolysis cases. Reporting Odds Ratios (RORs) and corresponding 95% confidence intervals (95%CI) for the association between antibiotics and rhabdomyolysis were calculated. An association was considered statistically significant when the lower limit of the 95%CI was greater than 1.0. Results: A total of 2,334,959 reports (including 7,685 rhabdomyolysis reports) were considered, after inclusion criteria were applied. Daptomycin had the greatest proportion of rhabdomyolysis reports, representing 5.5% of all daptomycin reports. Statistically significant rhabdomyolysis RORs (95% CI) for antibiotics were (in descending order):

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Section: Discussionsupporting

confidence: 91%

Section: Ivyspringmentioning

confidence: 99%

Rhabdomyolysis Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)

Teng¹,

Baus²,

Wilson³

et al. 2019

Int. J. Med. Sci.

View full text Add to dashboard Cite

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“…A literature search of fluoroquinolone‐induced rhabdomyolysis and corresponding review of citations yielded 16 case reports (Table ) . Fluoroquinolones involved in the cases were levofloxacin (7), ciprofloxacin (5), ofloxacin (2), gatifloxacin (1), moxifloxacin (1) and norfloxacin (1); 1 patient received both ofloxacin and levofloxacin.…”

Section: What Is New and Conclusionmentioning

confidence: 99%

Levofloxacin‐induced rhabdomyolysis in a patient on concurrent atorvastatin: Case report and literature review

2019

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Rhabdomyolysis is a clinical syndrome associated with electrolyte abnormalities and myoglobinuria. Signs and symptoms of rhabdomyolysis include elevated creatinine phosphokinase (CPK) and aspartate transaminase (AST), muscle pain, urine discoloration, fatigue, nausea, vomiting and fever. 1 If untreated, rhabdomyolysis can lead to renal failure and death. 2 Rhabdomyolysis can occur as a result of traumatic injury or chemical causes. 1-3 Prior case reports describing fluoroquinolone-induced rhabdomyolysis occurred within the first week of fluoroquinolone initiation. 4-10 Most of these involved the co-administration of simvastatin and either ciprofloxacin or levofloxacin. 4,5,7-10 We report a rare case of delayed-onset acute rhabdomyolysis that coincided with initiation of levofloxacin in a patient on long-term atorvastatin. A literature search of articles published in English through August 2018 was conducted using PubMed to identify other publications on fluoroquinolone-induced rhabdomyolysis with and without concomitant statin therapy. The following search terms were used alone and in combination: rhabdomyolysis, fluoroquinolone, statin, levofloxacin, atorvastatin. Citations of included articles were also reviewed to identify additional publications. | C A S E DE SCRIP TI ONA 65-year-old white male presented to an outside hospital with complaints of right knee pain, swelling, subjective fevers, chills, and inability to bear weight in the setting of prior right total knee arthroplasty. He was started on vancomycin and aztreonam for empiric treatment of a right knee prosthetic joint infection and was subsequently transferred to our facility for surgical intervention. The

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“…The diagnosis of RM usually depends on whether there is a certain cause of RM, which results in a more than five-fold increase in creatine kinase (CK) in the serum, as well as a high level myoglobin in the serum and urine [ 12 ]. Although levofloxacin can lead to RM [ 13 ], in our case, laboratory tests (such as white blood cell [WBC], neutrophil percentage and procalcitonin level) supported the etiology of a bacterial infection. In addition, the patient did not have any similar symptoms when he took levofloxacin before.…”

mentioning

confidence: 67%

A rare rhabdomyolysis appears after transrectal ultrasound guided prostate biopsy

Zhong

Cen

Chen

et al. 2021

Asian Journal of Urology

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Levofloxacin-induced rhabdomyolysis: a case report

Cited by 11 publications

References 8 publications

Rhabdomyolysis Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)

Rhabdomyolysis Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)

Levofloxacin‐induced rhabdomyolysis in a patient on concurrent atorvastatin: Case report and literature review

A rare rhabdomyolysis appears after transrectal ultrasound guided prostate biopsy

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