Levofloxacin-halloysite nanohybrid-loaded fibers based on poly (ethylene oxide) and sodium alginate: Fabrication, characterization, and antibacterial property

Fatahi, Yousef; Sanjabi, Maryam; Rakhshani, Amir; Motasadizadeh, Hamidreza; Darbasizadeh, Behzad; Bahadorikhalili, Saeed; Farhadnejad, Hassan

doi:10.1016/j.jddst.2021.102598

Cited by 15 publications

(6 citation statements)

References 45 publications

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“…From the results obtained in this paragraph, it can be said that the drug FMT was effectively incorporated into the nano-space between the layers of MMT particles; thus, the synthesis of MMT-FMT particles was successful. These results are in agreement with similar data reported in the literature (54).…”

Section: Characterization Of Mmt-fmt/ch Bio-nanocomposite Hydrogels 4...supporting

confidence: 94%

Montmorillonite-Famotidine/Chitosan Bio-nanocomposite Hydrogels as a Mucoadhesive/Gastroretentive Drug Delivery System

et al. 2022

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: The main purpose of the present study was to fabricate mucoadhesive bio-nanocomposite hydrogels to prolong the drug retention time in the stomach. In these bio-nanocomposite hydrogels, chitosan (CH) was used as a bioadhesive matrix, montmorillonite (MMT) was applied to modulate the release rate, and tripolyphosphate (TPP) was the cross-linking agent. The test samples were analyzed via different methods such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). Drug incorporation efficacy and mucoadhesive strength of these nanocomposite hydrogel beads were studied. Swelling and in vitro drug release behaviors of these bio-nanocomposite hydrogels were evaluated in simulated gastric fluid (SGF; pH 1.2). The optimized MMT-famotidine (FMT)/CH bio-nanocomposite hydrogels displayed a controllable and sustainable drug release profile with suitable mucoadhesion and prolonged retention time in the stomach. Thus, the results demonstrated that the fabricated mucoadhesive bio-nanocomposite hydrogels could remarkably increase the therapeutic efficacy and bioavailability of FMT by the oral route.

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Section: Characterization Of Mmt-fmt/ch Bio-nanocomposite Hydrogels 4...supporting

confidence: 94%

Montmorillonite-Famotidine/Chitosan Bio-nanocomposite Hydrogels as a Mucoadhesive/Gastroretentive Drug Delivery System

et al. 2022

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“…To assess the LEV and QS release kinetics, the in vitro release profile of the PEO-CS-LEV/PLGA-QS core-shell nanofibrous mats in PBS (pH 7.4) was fitted into different kinetic models ( Fatahi et al, 2021 ):

(Zero order kinetics model)

(First order kinetics model)

(Higuchi kinetics model)

(Korsmeyer–Peppas kinetics model)…”

Section: Methodsmentioning

confidence: 99%

“…n identifies the drug release mechanism. For cylindrical compounds, n ≤ 0.45, 0.45 < n < 1, n = 1, and n > 1 are indicative of the Fickian diffusion release, non-Fickian diffusion release, Case-II transport or zero-order kinetics, and supper case-II transport, respectively ( Fatahi et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Levofloxacin loaded poly (ethylene oxide)-chitosan/quercetin loaded poly (D,L-lactide-co-glycolide) core-shell electrospun nanofibers for burn wound healing

Monavari,

Sohrabi,

Motasadizadeh

et al. 2024

Front. Bioeng. Biotechnol.

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This study developed a new burn wound dressing based on core-shell nanofibers that co-deliver antibiotic and antioxidant drugs. For this purpose, poly(ethylene oxide) (PEO)-chitosan (CS)/poly(D,L-lactide-co-glycolide) (PLGA) core-shell nanofibers were fabricated through co-axial electrospinning technique. Antibiotic levofloxacin (LEV) and antioxidant quercetin (QS) were incorporated into the core and shell parts of PEO-CS/PLGA nanofibers, respectively. The drugs could bond to the polymer chains through hydrogen bonding, leading to their steady release for 168 h. An in vitro drug release study showed a burst effect followed by sustained release of LEV and QS from the nanofibers due to the Fickian diffusion. The NIH 3T3 fibroblast cell viability of the drug loaded core-shell nanofibers was comparable to that in the control (tissue culture polystyrene) implying biocompatibility of the nanofibers and their cell supportive role. However, there was no significant difference in cell viability between the drug loaded and drug free core-shell nanofibers. According to in vivo experiments, PEO-CS-LEV/PLGA-QS core-shell nanofibers could accelerate the healing process of a burn wound compared to a sterile gauze. Thanks to the synergistic therapeutic effect of LEV and QS, a significantly higher wound closure rate was recorded for the drug loaded core-shell nanofibrous dressing than the drug free nanofibers and control. Conclusively, PEO-CS-LEV/PLGA-QS core-shell nanofibers were shown to be a promising wound healing material that could drive the healing cascade through local co-delivery of LEV and QS to burn wounds.

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“…3D-printable nanocomposite ALG-based hydrogel with incorporated bifunctional nanomaterials prepared via functionalization of the pores and outer surfaces of periodic mesoporous organosilica with tetracycline and cell-adhesive poly-D-lysine exhibited pH-dependent release of antibiotic for 7 days and showed considerable antibiofilm activity against P. aeruginosa , although it did not reduce the biofilms of S. aureus and E. faecalis [ 226 ]. As a suitable biomaterial for wound dressings showing sustained LEV release and suitable good anti-bacterial activity, LEV-halloysite nanohybrid-loaded fibers based on poly(ethylene oxide) and Na–ALG were reported [ 227 ].…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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Levofloxacin-halloysite nanohybrid-loaded fibers based on poly (ethylene oxide) and sodium alginate: Fabrication, characterization, and antibacterial property

Cited by 15 publications

References 45 publications

Montmorillonite-Famotidine/Chitosan Bio-nanocomposite Hydrogels as a Mucoadhesive/Gastroretentive Drug Delivery System

Montmorillonite-Famotidine/Chitosan Bio-nanocomposite Hydrogels as a Mucoadhesive/Gastroretentive Drug Delivery System

Levofloxacin loaded poly (ethylene oxide)-chitosan/quercetin loaded poly (D,L-lactide-co-glycolide) core-shell electrospun nanofibers for burn wound healing

Advances in Nanostructures for Antimicrobial Therapy

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