Levofloxacin‐containing Triple and Sequential Therapy or Standard Sequential Therapy as the First Line Treatment for Helicobacter pylori Eradication in China

Abstract

Standard sequential therapy and 7-day levofloxacin triple therapy produced unacceptably therapeutic efficacy in China. Only levofloxacin-containing sequential therapy achieved borderline acceptable result. None of the regimens tested reliably achieved 90% or greater therapeutic efficacy in China.

Fluoroquinolone Sequential Therapy for Helicobacter pylori: A Meta‐analysis

“…The characteristics of the six trials included in the meta‐analysis are summarized in Table . All studies had at least one treatment arm that included a fluoroquinolone‐based sequential therapy and one arm that included a standard first‐line treatment therapy with either a standard triple or standard sequential therapy.…”

Ten day sequential versus 10 day modified bismuth quadruple therapy as empirical firstline and secondline treatment forHelicobacter pyloriin Chinese patients: an open label, randomised, crossover trial

“…The results of the sequential therapy in Asia were however variable, ranging from 81.9% in Korea,24 to 82.6% in China25 and to 90.5% in Taiwan 26. The recent study from Taiwan showed that extending sequential therapy from 10 to 14 days slightly increased the eradication rate by 3–4% 26…”

Review: Clinical Management of Helicobacter pylori Infection in China

“…performed a randomized multicenter trial and reported that the eradication rate of H. pylori after 10 days of sequential therapy was only 72.1% according to ITT analysis and only 76.5% according to PP analysis . While using levofloxacin instead of clarithromycin could only little improve the eradication rate, another clinical trials in Nanjing reported that the 10‐day standard sequential therapy and 10‐day levofloxacin sequential therapy eradication rate were 78.3% and 82.8%, by ITT analysis, respectively .…”