Levocarnitine regulates the growth of angiotensin II-induced myocardial fibrosis cells via TIMP-1

Jin, S.; Shi, Jing; Gu, Yiwen; Deng, Lei; Zhao, Chen; Wu, Chun; Zhao, Jiachen; Hai-ya, Wang; Jin, Li

doi:10.1515/biol-2022-0554

Cited by 2 publications

References 44 publications

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The Identification of Key Genes and Biological Pathways in Cardiac Arrest by Integrated Bioinformatics and Next Generation Sequencing Data Analysis

Vastrad,

Vastrad

2024

Preprint

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Cardiac arrest (CA) is a common cause of death world wide. The disease has lacks effective treatment. Efforts have been made to elucidate the molecular pathogenesis of CA, but the molecular mechanisms remain elusive. To identify key genes and pathways in CA, the next generation sequencing (NGS) GSE200117 dataset was downloaded from the Gene Expression Omnibus (GEO) database. DESeq2 tool was used to recognize differentially expressed genes (DEGs). Gene ontology (GO) and REACTOME pathway enrichment analyses were performed to analyze the DEGs and associated signal pathways in the g:Profiler database. The IID database was used to construct the protein-protein interaction (PPI) network, and modules analysis was performed using Cytoscape. A miRNA-hub gene regulatory network and TF-hub gene regulatory network were then constructed to screen miRNAs, TFs and hub genes by miRNet and NetworkAnalyst database and Cityscape software. Receiver operating characteristic curve (ROC) analysis used to verified the hub genes. In total, 844 DEGs were identified, comprising 414 up regulated genes and 430 down regulated genes. GO and REACTOME pathway enrichment analyses indicated that the DEGs for CA were mainly enriched in organonitrogen compound metabolic process, response to stimulus, translation and immune system. Ten hub genes (up-regulated: HSPA8, HOXA1, INCA1 and TP53; down-regulated: HSPB1, LMNA, SNCA, ADAMTSL4 and PDLIM7) were screened. We also predicted miRNAs (hsa-mir-1914-5p and hsa-mir-598-3p) and TFs (JUN and PRRX2) targeting hub genes. This study uses a series of bioinformatics technologies to obtain hug genes, miRNAs and TFs, and key pathways related to CA. These analysis results provide us with new ideas for finding biomarkers and treatment methods for CA.

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The Identification of Key Genes and Biological Pathways in Cardiac Arrest by Integrated Bioinformatics and Next Generation Sequencing Data Analysis

Vastrad,

Vastrad

2024

Preprint

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Use of metabolites, metabolithotropic agents and nutritional supplements in sports and sports medicine: a modern view on the problem

Bielenichev,

Gorchakova,

Doroshenko

et al. 2023

Modern Medical Technology

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Aim. The purpose of this study was to conduct an up-to-date semantic analysis of the results of our own research and literature data on the medical and pharmacological characteristics of metabolites, metabolitotropic agents and nutritional supplements, the peculiarities of their use in sports practice and sports medicine. Materials and methods. This study used bibliosemantic, analytical, logical, and generalization methods. The life sciences and biomedical information bibliographic databases MEDLINE, EMBASE, Medline (PubMed), Web of Science, and Cochrane Central were searched to find publications in English that matched the research keywords. The authors carried out an independent search and selection of articles, assessment of the quality of the data, compliance of the presentation and interpretation with the main idea of the study, with the formation of the final list of references. Results. Based on the analysis of modern literature data and the results of our own studies, a generalized medical and pharmacological characteristic of metabolite agents, metabolitotropic drugs and nutritional supplements that can influence the main and compensatory mechanisms of macroergic phosphates production under the influence of physical activity is presented. The mechanisms of action, indications for use and main side effects of drugs and food additives based on ATP, malate, succinate, citrate, pyruvate, carnitine, carnosine, etc. are presented. Conclusions. Semantic analysis data indicate that an urgent problem for sports medicine physicians and pharmacologists is the development and use of metabolites, metabolitotropic agents and nutritional supplements, as well as approaches to their rational combination to improve energy metabolism, replenish ATP reserves in the body that will help ensure the intensity muscular activity and simultaneously protect target organs.

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Levocarnitine regulates the growth of angiotensin II-induced myocardial fibrosis cells via TIMP-1

Cited by 2 publications

References 44 publications

The Identification of Key Genes and Biological Pathways in Cardiac Arrest by Integrated Bioinformatics and Next Generation Sequencing Data Analysis

The Identification of Key Genes and Biological Pathways in Cardiac Arrest by Integrated Bioinformatics and Next Generation Sequencing Data Analysis

Use of metabolites, metabolithotropic agents and nutritional supplements in sports and sports medicine: a modern view on the problem

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