Levobupivacaine Versus Racemic Bupivacaine for Spinal Anesthesia

Update on local anesthetics: focus on levobupivacaine

“…Not surprisingly therefore, bupivacaine remains the most widely and cost-efficient long acting local anesthetic used in spinal anesthesia. A surgical sensory and motor block of similar characteristics and recovery over equal dose ranges of levobupivacaine and bupivacaine was demonstrated in healthy volunteers (Alley et al 2002) and confirmed in surgical patients (Glaser et al 2002; Lee et al 2003; Casati et al 2004a; Fattorini et al 2006) (Table 1). The regression of motor block was significantly more rapid after levobupivacaine and ropivacaine than bupivacaine in a study by Casati and colleagues, which may be advantageous for early ambulation after day-case surgery (Casati et al 2004a).…”

Comparison of 0.25% Levobupivacaine, 0.25% Bupivacaine, and 0.125% Bupivacaine for Duration and Magnitude of Action in Peripheral Arterial Blood Flow Induced by Sympathetic Block in Dogs

“…The duration of sensory block induced by levobupivacaine may be similar to bupivacaine in neuraxial blocks. [6][7][8][9][10][11] However, the duration of motor block induced by levobupivacaine in neuraxial blocks or peripheralnerve blocks may be shorter than that of bupivacaine. 9,[12][13][14][15] The duration and magnitude of action of sympathetic block induced by levobupivacaine may be less compared with bupivacaine, according to our results.…”

“…[1][2][3][4] Sensory and motor blocks with levobupivacaine have been examined in human and animal experiments. [5][6][7][8][9][10][11][12][13][14][15] The duration of action of levobupivacaine when applied for centroneuraxis or peripheral-nerve block is similar to, or shorter than, that of bupivacaine. However, little is known about the duration of action of levobupivacaine when applied for sympathetic block.…”

Abstracts and Highlight Papers of the 37th Annual European Society of Regional Anesthesia & Pain Therapy (ESRA) Congress 2018: E-Poster Discussion Abstracts

“…E-POSTER DISCUSSION SESSIONS 03 -CASE REPORTS 1 ACUTE SUBDURAL HEMORRHAGE FOLLOWING SPINAL ANAESTHESIA: A CASE REPORT Li L. 1 , and Joseph A. 2 1 Singhealth, Department of Anaesthesia and Surgical Intensive Care, Singapore, Singapore, 2 Changi General Hospital, Department of Anaesthesia and Surgical Intensive Care, Singapore, Singapore.…”