Levetiracetam-Induced Reversible Autistic Regression

Camacho, Ana; Espín, José Carlos; Núñez, Noemí; Simón, Rogelio

doi:10.1016/j.pediatrneurol.2012.04.002

Cited by 14 publications

(7 citation statements)

References 12 publications

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“…Some children with drug resistant epilepsy may show regression in intellectual abilities over time [3]. The causes of regression may include the etiology of the underlying epilepsy, the spike discharges on electroencephalogram (EEG) outputs, the seizures themselves and a variety of medications [4,5], but there is no known biomarker for disease severity or neurocognitive comorbidity.…”

Section: Introductionmentioning

confidence: 99%

Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?

Choi

Kim

et al. 2020

BMC Neurol

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Background: The search for noninvasive biomarkers of neuroinflammation and neurodegeneration has focused on various neurological disorders, including epilepsy. We sought to determine whether α-synuclein and cytokines are correlated with the degree of neuroinflammation and/or neurodegeneration in children with epilepsy and with acquired demyelinating disorders of the central nervous system (CNS), as a prototype of autoimmune neuroinflammatory disorders. Methods: We analyzed serum and exosome levels of α-synuclein and serum proinflammatory and antiinflammatory cytokines among 115 children with epilepsy and 10 acquired demyelinating disorders of the CNS and compared to 146 controls. Patients were enrolled prospectively and blood was obtained from patients within 48 h after acute afebrile seizure attacks or relapse of neurological symptoms. Acquired demyelinating disorders of the CNS include acute disseminated encephalomyelitis, multiple sclerosis, neuromyelitis optica spectrum disorders, and transverse myelitis. The controls were healthy age-matched children. The serum exosomes were extracted with ExoQuick exosome precipitation solution. Serum α-synuclein levels and serum levels of cytokines including IFN-β, IFN-γ, IL-1β, IL-6, IL-10 and TNF-α were measured using single and multiplex ELISA kits. Data were analyzed and compared with measures of disease severity, such as age at disease onset, duration of disease, and numbers of antiepileptic drug in use.

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Section: Introductionmentioning

confidence: 99%

Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?

Choi

Kim

et al. 2020

BMC Neurol

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“…132 Another case report details a reversible autistic regressive episode in a biologically vulnerable young girl, which resolved after the discontinuation of levetiracetam. 133 When used in young children, nearly 16% of the patients in one trial discontinued levetiracetam due to behavioral effects. 134 While there may be an elevated risk of adverse psychiatric symptoms in patients with intellectual disabilities with prior behavior problems, psychiatric history, or history of status epilepticus, improved alertness and behavior in patients with learning disabilities has also been described.…”

Section: Lamotriginementioning

confidence: 99%

The Effects of Antiepileptic Drugs on Pediatric Cognition, Mood, and Behavior

Afzal

Anam

2016

J Pediatr Epilepsy

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However, the secondary use of AEDs in mood and behavior disorders has increased manifold. 2 This article aims to discuss the use and effects of AEDs in pediatric mood and behavior Keywords ► antiepileptic drugs ► mood ► behavior ► cognition ► adverse effects AbstractIn the past three decades, several new antiepileptic drugs (AEDs) have been marketed across the world, although with a surprisingly modest improvement in overall seizure control. During the same period, the use of AEDs as mood stabilizing or impulse control agents has been trending upwards, due to a notable increase in comorbid mood and behavior disorders in children, and a desire to address these pharmacologically. AEDs have been frequently associated with adverse mood and behavior changes, along with neuropsychiatric effects on attention, memory, and cognition. In this review, we discuss the use and adverse effects of the first-(e.g., barbiturates, carbamazepine, ethosuximide, phenytoin, valproate), second-(e.g., clobazam, felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, tiagabine, topiramate, stiripentol, vigabatrin, zonisamide), and third-(e.g., brivaracetam, eslicarbazepine acetate, lacosamide, perampanel, retigabine, rufinamide) generation AEDs in pediatric mood and behavior disorders. We also address what is currently known about the potential longterm neuropsychiatric consequences of AEDs. The distinction between the U.S. Food and Drug Administration-approved drugs versus off-label use of these drugs in the pediatric population is also examined.

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“…The finding that some of these features can be partially reversible by antiepileptic therapy requires significant further clinical research (Camacho et al 2012). …”

Section: Autismmentioning

confidence: 99%

Single-Gene Determinants of Epilepsy Comorbidity

Noebels

2015

Cold Spring Harb Perspect Med

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Levetiracetam-Induced Reversible Autistic Regression

Cited by 14 publications

References 12 publications

Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?

Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?

The Effects of Antiepileptic Drugs on Pediatric Cognition, Mood, and Behavior

Single-Gene Determinants of Epilepsy Comorbidity

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