Levetiracetam—induced hyponatremia

Roşca, Elena Cecilia; Simu, Mihaela

doi:10.1007/s13760-017-0825-4

Cited by 13 publications

(11 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another report, LEV induced hyponatremia and thrombocytopenia 25,26 . The previously-mentioned information provides a logical justification for our result, which showed a positive relationship between bone marrow density and bone resorption marker urinary deoxypyridinoline using Pearson's correlation coefficient.…”

mentioning

confidence: 87%

Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients

El-Haggar

Mostafa

Allah

et al. 2018

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

The purpose of this study was to determine the effect of lamotrigine (LTG) and levetiracetam (LEV) as mono- and polytherapy on biochemical markers of bone turnover and bone mineral density in Egyptian adult patients with epilepsy. Methods Forty-eight patients were divided into four groups: two received monotherapy of either LTG or LEV, and the other two groups received polytherapy comprising (valproate [VPA] + LTG or VPA + LEV). Thirty matched healthy participants were included in the study. Participants completed a nutritional and physical activity questionnaire. Biochemical markers of bone and mineral metabolism and bone mineral density of the lumbar spine were measured at baseline and at six months. Results In the LEV monotherapy group, the bone formation markers showed a significant decrease in serum alkaline phosphatase and serum osteocalcin levels while the bone resorption marker showed a significant increase in urinary deoxypyridinoline levels. After six months of treatment, bone mineral density showed a significant decrease in all treated groups, while among monotherapy groups, this significant decrease was more prevalent in the LEV monotherapy group compared with the LTG monotherapy group. Furthermore, there was significant negative correlation between urinary deoxypyridinoline levels and bone mineral density in the LEV monotherapy group. Conclusion Using new generation antiepileptics, LEV monotherapies and polytherapy showed harmful effects on bone but LTG did not.

show abstract

mentioning

confidence: 87%

Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients

El-Haggar

Mostafa

Allah

et al. 2018

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…It acts as a neuromodulator binding to a synaptic vesicle glycoprotein (SV2A) and by inhibiting presynaptic calcium channels. Association of some cases of hyponatremia and use of levetiracetam has been documented [90,107].…”

Section: Levetiracetammentioning

confidence: 99%

Hyponatremia and Psychotropic Drugs

Cortés¹,

Muñoz²

2019

Fluid and Electrolyte Disorders

View full text Add to dashboard Cite

Given the widespread use of psychotropic drugs in the population, it's important to consider hyponatremia as an avoidable and reversible adverse effect and include the detection of high-risk subjects to establish safer medications, as well as early detection measures in routine clinical practice. Although hyponatremia has been especially associated with serotonergic antidepressants (SSRIs), there is also an elevated risk with tricyclics, duals and heterocyclic antidepressants, due to the different mechanisms of action at the renal tubular level and the release of ADH. Hyponatremia secondary to tricyclics with slow CYP2D6 metabolizers have higher plasma concentrations of antidepressants metabolized by CYP2D6. Hyponatremia secondary to SSRIs appears in the first week of treatment, it is "not dose-dependent" and normalization of natremia occurs between 2 and 20 days after stopping the medication. Bupropion, trazodone, mianserin, reboxetine and agomelatine are a safe alternative. Also antiepileptics have been related to hyponatremia. Both typical and atypical antipsychotics have been exposed to an increased risk of hyponatremia, even after adjusted factors such as age, sex and comorbidity. Other factors that favor the onset of hyponatremia act synergistically with psychotropic drugs, such as: advanced age, female sex, concomitant diuretic intake, low body weight and low sodium levels; NSAID, ACEIs, and warm.

show abstract

“…1 Lev-associated hyponatremia, hypokalemia, and hypomagnesemia have been described in adult patients. [2][3][4][5][6][7][8] However, there are no reports on the above Lev-associated disorders in children with epilepsy treated with Lev monotherapy.…”

Section: Serum Sodium Potassium and Magnesium In Children With Epilmentioning

confidence: 99%

“…In the literature, hyponatremia has been reported in 5 asymptomatic adults during Lev treatment. [2][3][4][5][6] Hyponatremia was found as early as 3 days and up to 2 years after initiation of Lev treatment.…”

Section: Serum Sodium Potassium and Magnesium In Children With Epilmentioning

confidence: 99%

“…3 Advanced age and female gender have been suggested as predisposing factors for Lev-associated hyponatremia. [2][3][4][5][6] Hypokalemia and hypomagnesemia have been described in 3 asymptomatic adult patients, 2 days to 6 weeks after the administration of Lev. Transcellular shift of K + and renal tubular disorder have been proposed as possible causes for these disorders.…”

Section: Serum Sodium Potassium and Magnesium In Children With Epilmentioning

confidence: 99%

See 1 more Smart Citation

Serum sodium, potassium, and magnesium in children with epilepsy treated with levetiracetam monotherapy: A prospective study

et al. 2018

View full text Add to dashboard Cite

Levetiracetam—induced hyponatremia

Cited by 13 publications

References 6 publications

Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients

Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients

Hyponatremia and Psychotropic Drugs

Serum sodium, potassium, and magnesium in children with epilepsy treated with levetiracetam monotherapy: A prospective study

Contact Info

Product

Resources

About