Levetiracetam and topiramate poisoning: Two overdoses on those drugs with no lasting effects

Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center

“…Our findings with levetiracetam also largely match the reported literature [ 17 , [22] , [23] , [24] , [25] , [26] , [27] , [28] ]. In our study, approximately 45 % of patients with a levetiracetam serum/plasma level of 80 mg/L or higher were asymptomatic.…”

“…Dose adjustments are required for those with renal insufficiency [ 3 , 4 ]. Overdoses are typically well tolerated, with the majority of patients remaining asymptomatic [ 17 , [22] , [23] , [24] , [25] , [26] , [27] , [28] ]. The proposed reference range is 12–46 mg/L [ 19 ].…”

Topiramate intoxications & hemodialysis – Literature review and the first case report of a massive suicidal intoxication treated with hemodialysis

“… Case ID Patient gender Patient age Patient body weight (Kg) Topiramate (ingested dose in mg) Topiramate (ingested dose in mg//kg body weight) Co-ingestion Seizures Symptoms Concentration topiramate (Measured, ug/ml) Gastric lavage Activated charcoal/sorbitol Intubation Hemodialysis Outcome Sarfaraz_1 [22] F 21 43.7 1500 34.3 Yes None Asymptomatic n.a. No Yes No No recovered without sequelae Sarfaraz_2 [22] F 21 43.7 175 4.0 Yes None Asymptomatic n.a. No Yes No No recovered without sequelae Vazques_1 [23] F 24 n.a.…”

Electrocardiography abnormality in a suicide attempt with levetiracetam

“…Adverse effects were not observed in infant and children following LEV overdose. 11,12 Sarfaraz et al 13 also detected no neurologic, cardiovascular or gastrointestinal adverse effects in an adult who ingested 600 g LEV and 1.5 g topiramate in a suicide attempt. By contrast, Barrueto et al intubated an adult due to impaired consciousness after ingestion of 30 g LEV and reported a global decrease in DTRs and muscle tone.…”