Abstract:Enzymes that catalyze post-translational modifications of peptides and
proteins (PTM-enzymes) – proteases, protein ligases, oxidoreductases,
kinases, and other transferases - are foundational to our understanding
of health and disease and empower applications in chemical biology,
synthetic biology, and biomedicine. To fully harness the potential of
PTM-enzymes, there is a critical need to decipher their enzymatic and
biological mechanisms, develop molecules that can probe and reprogram
them, and endow them wit… Show more
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