Leveraging the photophysical properties of rhenium(I) tricarbonyl complexes for biomedical applications

Wilson, Justin J.

doi:10.1016/bs.adioch.2022.04.005

Cited by 3 publications

(2 citation statements)

References 156 publications

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“…Although rhenium (Re) carbonyl complexes have been thoroughly investigated for their photochemical and catalytic properties, recent studies have revealed their potential for biomedical applications. , In particular, this class of compounds has found use as CORMs, − with several of them being specifically investigated as therapeutic agents for IRI. The Re(II) carbonyl complexes of the general formula cis -[Re(CO) 2 Br 2 L 2 ] n − (Chart ) are promising examples of Re-based CORMs for IRI .…”

Section: Gasotransmitter Deliverymentioning

confidence: 99%

Metal Coordination Complexes as Therapeutic Agents for Ischemia-Reperfusion Injury

Bigham

Wilson

2023

J. Am. Chem. Soc.

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Ischemia-reperfusion injury (IRI), which describes the cell damage and death that occurs after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor within the mortality rates of heart disease and stroke patients. At the cellular level, the return of oxygen triggers an increase in reactive oxygen species (ROS) and mitochondrial calcium ( m Ca 2+ ) overload, which both contribute to cell death. Despite the widespread occurrence of IRI in different pathological conditions, there are currently no clinically approved therapeutic agents for its management. In this Perspective, we will briefly discuss the current therapeutic options for IRI and then describe in great detail the potential role and arising applications of metal-containing coordination and organometallic complexes for treating this condition. This Perspective categorizes these metal compounds based on their mechanisms of action, which include their use as delivery agents for gasotransmitters, inhibitors of m Ca 2+ uptake, and catalysts for the decomposition of ROS. Lastly, the challenges and opportunities for inorganic chemistry approaches to manage IRI are discussed.

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Section: Gasotransmitter Deliverymentioning

confidence: 99%

Metal Coordination Complexes as Therapeutic Agents for Ischemia-Reperfusion Injury

Bigham

Wilson

2023

J. Am. Chem. Soc.

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“…Cancer stands as the second leading cause of death worldwide, contributing to a significant global disease burden with approximately 10 million annual deaths. , Conventional cancer treatments, such as surgery, radiotherapy, and chemotherapy, have notable limitations, including severe side effects on healthy organs and drug resistance . Consequently, discovering of alternative and more selective anticancer drugs is a highly desirable goal and remains to be an active field of research, where metallopharmaceuticals are playing a significant role. − Smart drugs that provide a combination of diagnostics and therapy, “theranostic agents”, are of recent origin and have also received a surge of research interest. , Radioactive 186 Re and 188 Re have been extensively used in clinical treatment of cancer, , and in the past decade, there has been an enormous interest in the exploitation of the rich photophysical properties of rhenium complexes for diverse imaging modalities and therapeutic biomedical applications. − In particular, rhenium carbonyl complexes have been shown to be novel anticancer agents, , inhibitors of the SARS-CoV-2 main protease, , and more recently therapeutic agents for schemia-reperfusion injury (IRI) . In general, the mechanisms of action of Re(I) anticancer complexes containing the fac -[Re(CO) 3 ] + core are quite distinct from that of conventional platinum agents, ,− that is dependent on covalent bond formation to DNA .…”

Section: Introductionmentioning

confidence: 99%

Novel Re(I) Complexes as Potential Selective Theranostic Agents in Cancer Cells and In Vivo in Caenorhabditis elegans Tumoral Strains

Marco,

Ashoo,

Hernández-García

et al. 2024

J. Med. Chem.

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A series of rhenium(I) complexes of the type fac -[Re(CO) 3 (N^N)L] 0/+ , Re1 – Re9 , was synthesized, where N^N = benzimidazole-derived bidentate ligand with an ester functionality and L = chloride or pyridine-type ligand. The new compounds demonstrated potent activity toward ovarian A2780 cancer cells. The most active complexes, Re7 – Re9 , incorporating 4-NMe 2 py, exhibited remarkable activity in 3D HeLa spheroids. The emission in the red region of Re9 , which contains an electron-deficient benzothiazole moiety, allowed its operability as a bioimaging tool for in vitro and in vivo visualization. Re9 effectivity was tested in two different C. elegans tumoral strains, JK1466 and MT2124, to broaden the oncogenic pathways studied. The results showed that Re9 was able to reduce the tumor growth in both strains by increasing the ROS production inside the cells. Moreover, the selectivity of the compound toward cancerous cells was remarkable as it did not affect neither the development nor the progeny of the nematodes.

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Synthesis, characterisation and cytotoxicity of rhenium complexes with Bis(2-pyridylmethyl)amine and two of its derivatives

Schutte-Smith,

Fourie,

van Staden

et al. 2024

Polyhedron

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Leveraging the photophysical properties of rhenium(I) tricarbonyl complexes for biomedical applications

Cited by 3 publications

References 156 publications

Metal Coordination Complexes as Therapeutic Agents for Ischemia-Reperfusion Injury

Metal Coordination Complexes as Therapeutic Agents for Ischemia-Reperfusion Injury

Novel Re(I) Complexes as Potential Selective Theranostic Agents in Cancer Cells and In Vivo in Caenorhabditis elegans Tumoral Strains

Synthesis, characterisation and cytotoxicity of rhenium complexes with Bis(2-pyridylmethyl)amine and two of its derivatives

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