Leveraging Surface Plasmon Resonance to Dissect the Interfacial Properties of Nanoparticles: Implications for Tissue Binding and Tumor Penetration

Wadajkar, Aniket S.; Dancy, Jimena G.; Carney, Christine P.; Hampton, Brian; Ames, Heather M.; Winkles, Jeffrey A.; Woodworth, Graeme F.; Kim, Anthony J.

doi:10.1016/j.nano.2019.102024

Cited by 12 publications

(15 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We explored how the PLGA sequence distribution affects the drug release properties of PEG-PLGA. Paclitaxel (PTX)-loaded PEG-PLGA nanoparticles (“PEG-PLGA/PTX NPs”; having a hydrodynamic diameter of ∼700 nm) were prepared from OLG1, OLG2, and OLG3 using the emulsion-evaporation procedure . The size and drug loading characteristics of the resultant PEG-PLGA/PTX NPs are summarized in Figure a and Table S2.…”

mentioning

confidence: 99%

Strategy for Synthesis of Statistically Sequence-Controlled Uniform PLGA and Effects of Sequence Distribution on Interaction and Drug Release Properties

2021

View full text Add to dashboard Cite

Extensive studies have been conducted to elucidate the effects of such parameters as molecular weight, polydispersity, and composition on the controlled release properties of poly(D,Llactic-co-glycolic acid) (PLGA). However, studies dealing with the effect of monomer sequence distribution have been sparse mainly because of the difficulty of precisely controlling the monomer sequence in PLGA. Herein, we present a semibatch copolymerization strategy that enables the production of statistically sequencecontrolled "uniform PLGA" polymers through control of the rate of comonomer addition. Using this method, a series of PEG− PLGA samples having a comparable molecular weight and composition but different sequence distributions (uniform vs gradient) were prepared. The properties of these materials (PEG crystallization/melting, hygroscopicity, aqueous sol−gel transition, drug release kinetics) were found to significantly vary, demonstrating that sequence control only at the statistical level still significantly influences the properties of PLGA. Most notably, uniform PLGA exhibited the more sustained drug release behavior compared to gradient PLGA.

show abstract

mentioning

confidence: 99%

Strategy for Synthesis of Statistically Sequence-Controlled Uniform PLGA and Effects of Sequence Distribution on Interaction and Drug Release Properties

2021

View full text Add to dashboard Cite

show abstract

“…Finally, the drug is released inside the cell ( Dong et al, 2019 ). Tumor tissue penetration is an indispensable and important link for the efficacy of nanoformulations ( Wadajkar et al, 2019 ).…”

Section: Current Situation and Future Prospects Of Ua Nanoformulationsmentioning

confidence: 99%

Nanoformulations of Ursolic Acid: A Modern Natural Anticancer Molecule

et al. 2021

View full text Add to dashboard Cite

Background: Ursolic acid (UA) is a natural pentacyclic triterpene derived from fruit, herb, and other plants. UA can act on molecular targets of various signaling pathways, inhibit the growth of cancer cells, promote cycle stagnation, and induce apoptosis, thereby exerting anticancer activity. However, its poor water-solubility, low intestinal mucosal absorption, and low bioavailability restrict its clinical application. In order to overcome these deficiencies, nanotechnology, has been applied to the pharmacological study of UA.Objective: In this review, we focused on the absorption, distribution, and elimination pharmacokinetics of UA in vivo, as well as on the research progress in various UA nanoformulations, in the hope of providing reference information for the research on the anticancer activity of UA.Methods: Relevant research articles on Pubmed and Web of Science in recent years were searched selectively by using the keywords and subheadings, and were summarized systematically.Key finding: The improvement of the antitumor ability of the UA nanoformulations is mainly due to the improvement of the bioavailability and the enhancement of the targeting ability of the UA molecules. UA nanoformulations can even be combined with computational imaging technology for monitoring or diagnosis.Conclusion: Currently, a variety of UA nanoformulations, such as micelles, liposomes, and nanoparticles, which can increase the solubility and bioactivity of UA, while promoting the accumulation of UA in tumor tissues, have been prepared. Although the research of UA in the nanofield has made great progress, there is still a long way to go before the clinical application of UA nanoformulations.

show abstract

“…Therapeutic efficacy of drug nanovehicles for cancer applications is significantly impaired by limited tumor tissue penetration due to a physical barrier formed by extracellular matrix (ECM) proteins. In this regard, SPR has been recently expanded as a method to examine the interfacial properties of liposomes, by analyzing their binding properties toward surface immobilized tumor ECM proteins as a surrogate for their ability to penetrate solid tumors (Wadajkar et al, 2019 ).…”

Section: Applications Of Spr-based Biosensors In the Study Of Lnpsmentioning

confidence: 99%

Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery

et al. 2021

View full text Add to dashboard Cite

The development of drug carriers based in lipid nanoparticles (LNPs) aims toward the synthesis of non-toxic multifunctional nanovehicles that can bypass the immune system and allow specific site targeting, controlled release and complete degradation of the carrier components. Among label free techniques, Surface Plasmon Resonance (SPR) biosensing is a versatile tool to study LNPs in the field of nanotherapeutics research. SPR, widely used for the analysis of molecular interactions, is based on the immobilization of one of the interacting partners to the sensor surface, which can be easily achieved in the case of LNPs by hydrophobic attachment onto commercial lipid- capture sensor chips. In the last years SPR technology has emerged as an interesting strategy for studying molecular aspects of drug delivery that determines the efficacy of the nanotherapeutical such as LNPs' interactions with biological targets, with serum proteins and with tumor extracelullar matrix. Moreover, SPR has contributed to the obtention and characterization of LNPs, gathering information about the interplay between components of the formulations, their response to organic molecules and, more recently, the quantification and molecular characterization of exosomes. By the combination of available sensor platforms, assay quickness and straight forward platform adaptation for new carrier systems, SPR is becoming a high throughput technique for LNPs' characterization and analysis.

show abstract

Leveraging Surface Plasmon Resonance to Dissect the Interfacial Properties of Nanoparticles: Implications for Tissue Binding and Tumor Penetration

Cited by 12 publications

References 43 publications

Strategy for Synthesis of Statistically Sequence-Controlled Uniform PLGA and Effects of Sequence Distribution on Interaction and Drug Release Properties

Strategy for Synthesis of Statistically Sequence-Controlled Uniform PLGA and Effects of Sequence Distribution on Interaction and Drug Release Properties

Nanoformulations of Ursolic Acid: A Modern Natural Anticancer Molecule

Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery

Contact Info

Product

Resources

About