Leveraging multi-shell diffusion for studies of brain development in youth and young adulthood

Pines, Adam; Cieslak, Matthew; Larsen, Bart; Baum, Graham L.; Cook, Philip A.; Adebimpe, Azeez; Davila, Diego; Elliott, Mark A.; Jirsaraie, Robert J.; Murtha, Kristin; Oathes, Desmond J.; Piiwaa, Kayla; Rosen, Adon F.G.; Rush, Sage; Shinohara, Russell T.; Bassett, Danielle S.; Roalf, David R.; Satterthwaite, Theodore D.

doi:10.1016/j.dcn.2020.100788

Cited by 75 publications

(62 citation statements)

References 87 publications

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“…Still, to extract all bundles of interest, we needed to use multiple automated algorithms and perform rigorous visual inspection to make sure all algorithms yielded comparable bundles. The diffusion sequence relied on only one b-value, and future acquisitions with multiple b-values could further improve capturing fine-grained changes (Pines et al, 2020). Given the partial volume effect of PET, pathology at the cortical endpoints might be slightly affected with white matter uptake.…”

Section: Discussionmentioning

confidence: 99%

Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer’s disease

Binette

Theaud

Rheault

et al. 2020

Preprint

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Beta-amyloid (Aβ) and tau proteins, the pathological hallmarks of Alzheimer’s disease (AD), are believed to spread through connected regions. Combining diffusion imaging and positron emission tomography, we investigated associations between Aβ, tau and white matter microstructure specifically in bundles connecting brain regions in which AD pathology accumulates. In 126 cognitively normal elderly at risk of AD, we focussed on free-water corrected diffusion measures in the cingulum, posterior cingulum, fornix and uncinate fasciculus. We found higher tissue fractional anisotropy and lower mean and radial diffusivity related to increased Aβ at the cortical endpoints of the cingulum and fornix. We observed similar but stronger associations in the uncinate fasciculus, but with increased Aβ and tau at the endpoints of this bundle. This consistent pattern of associations, with opposite directionality to the usual degeneration pattern in symptomatic individuals, suggests more restricted diffusion in bundles vulnerable to preclinical AD pathology.

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Section: Discussionmentioning

confidence: 99%

Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer’s disease

Binette

Theaud

Rheault

et al. 2020

Preprint

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“…Essentially, these models derive more nuanced characterizations of white matter with diffusion scans that measure both diffusion direction and gradient strength. An example, Mean Apparent Propagator MRI (MAP_MRI) has shown promising accuracy (Özarslan et al, 2013) and limited evidence in one study of development suggests improvement over typical DTI in measuring age-related associations (Pines et al, 2020). Future studies should employ these methods to further explore how white matter microstructural development is related to the development of different executive functions.…”

Section: Future Directionsmentioning

confidence: 99%

Development of white matter microstructure and executive functions during childhood and adolescence: a review of diffusion MRI studies

Goddings¹,

Roalf²,

Lebel³

et al. 2020

Preprint

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Diffusion magnetic resonance imaging (dMRI) provides indirect measures of white matter microstructure that can be used to make inferences about structural connectivity within the brain. Over the last decade, a growing literature of cross-sectional and longitudinal studies have documented relationships between dMRI indices and cognitive development. In this review, we provide a brief overview of dMRI methods and how they can be used to study white matter and connectivity, briefly discuss challenges with using dMRI in child and adolescent populations, and review the extant literature examining the links between dMRI indices and executive functions during development. We explore the links between white matter microstructure and specific executive functions: inhibition, working memory and cognitive shifting, as well as performance on complex executive function tasks. Where there is concordance in findings across studies, this is highlighted, and potential explanations for discrepancies between results are discussed. Finally, we explore future directions that are necessary to better understand the links between child and adolescent development of executive functions and structural connectivity of the brain.

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“…By comparison, FA measurements can be conflated by crossing fibres and extra-axonal signal contamination ( Jones et al, 2013 ; Bach et al, 2014 ; Beaulieu, 2009 ), making biophysical interpretations challenging. With the use of robust neuroimaging studies using high-quality dMRI data, it is possible to unravel the specific neurobiological links between brain structure and developmental factors during this sensitive period of growth ( Pines et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal patterns of white matter fibre density and morphology in children are associated with age and pubertal stage

Genc

Malpas

Gulenc

et al. 2020

Developmental Cognitive Neuroscience

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Highlights Fibre properties derived from fixel-based analysis are sensitive to development. Age-related patterns are consistent with previous diffusion tensor studies. Pubertal stage correlates with fibre density and morphology in the right SLF. Pubertal stage correlates with fibre morphology in the right ILF. Pubertal progression interacts with age for longitudinal fibre density changes.

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Leveraging multi-shell diffusion for studies of brain development in youth and young adulthood

Cited by 75 publications

References 87 publications

Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer’s disease

Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer’s disease

Development of white matter microstructure and executive functions during childhood and adolescence: a review of diffusion MRI studies

Longitudinal patterns of white matter fibre density and morphology in children are associated with age and pubertal stage

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