Leveraging molecular quantitative trait loci to comprehend complex diseases/traits from the omics perspective

Zhu, Zijun; Chen, Xinyu; Zhang, Sainan; Yu, Rui; Qi, Changlu; Cheng, Liang; Zhang, Xue

doi:10.1007/s00439-023-02602-9

Hum. Genet.

2023

DOI: 10.1007/s00439-023-02602-9

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Leveraging molecular quantitative trait loci to comprehend complex diseases/traits from the omics perspective

Zijun Zhu,

Xinyu Chen,

Sainan Zhang

et al.

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2024

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The genetic basis of autoimmunity seen through the lens of T cell functional traits

Lagattuta,

Park,

Rumker

et al. 2024

Nat Commun

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Autoimmune disease heritability is enriched in T cell-specific regulatory regions of the genome. Modern-day T cell datasets now enable association studies between single nucleotide polymorphisms (SNPs) and a myriad of molecular phenotypes, including chromatin accessibility, gene expression, transcriptional programs, T cell antigen receptor (TCR) amino acid usage, and cell state abundances. Such studies have identified hundreds of quantitative trait loci (QTLs) in T cells that colocalize with genetic risk for autoimmune disease. The key challenge facing immunologists today lies in synthesizing these results toward a unified understanding of the autoimmune T cell: which genes, cell states, and antigens drive tissue destruction?

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The genetic basis of autoimmunity seen through the lens of T cell functional traits

Lagattuta,

Park,

Rumker

et al. 2024

Nat Commun

View full text Add to dashboard Cite

show abstract

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Leveraging molecular quantitative trait loci to comprehend complex diseases/traits from the omics perspective

Cited by 1 publication

References 173 publications

The genetic basis of autoimmunity seen through the lens of T cell functional traits

The genetic basis of autoimmunity seen through the lens of T cell functional traits

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