Leveraging metabolic modeling and machine learning to uncover modulators of quiescence depth
Alec Eames,
Sriram Chandrasekaran
Abstract:Quiescence, a temporary withdrawal from the cell cycle, plays a key role in tissue homeostasis and regeneration. Quiescence is increasingly viewed as a continuum between shallow and deep quiescence, reflecting different potentials to proliferate. The depth of quiescence is altered in a range of diseases and during aging. Here, we leveraged genome-scale metabolic modeling to define the metabolic and epigenetic changes that take place with quiescence deepening. We discovered contrasting changes in lipid cataboli… Show more
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