Leveraging lncRNA-miRNA-mRNA network to reveal anti-Spiroplasma eriocheiris infection mechanisms in Macrobrachium nipponense

Ou, Jiangtao; Chen, Hao; Luan, Xiaoqi; Ju, Rong; Sun, Yu; Zhang, Benhou; Bian, Yunxia; Meng, Yusuo; Ji, Hao; Zhao, Wei

doi:10.1016/j.aquaculture.2022.738286

Cited by 4 publications

(4 citation statements)

References 69 publications

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“…In M. nipponense the miR-71-3p star sequence has the ability to inhibit clotting through the targeting of PCE a pro-clotting enzyme [ 40 ]. The miR-71-3p star sequence is an important part of the immune response to bacterial infection of the river prawn through regulating clotting in conjunction with a long non-coding RNA (lncRNA) lncRNA transcript_11191 [ 40 ]. In response to S. eriocheiris infection miR-71-3p was upregulated and found to act in a trinity with lncRNA transcript_11191 and PCE [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…The miR-71-3p star sequence is an important part of the immune response to bacterial infection of the river prawn through regulating clotting in conjunction with a long non-coding RNA (lncRNA) lncRNA transcript_11191 [ 40 ]. In response to S. eriocheiris infection miR-71-3p was upregulated and found to act in a trinity with lncRNA transcript_11191 and PCE [ 40 ]. The proposed mechanism from Ou et al is of lncRNA transcript_11191 acting as a sponge and competitively binding to miR-71-3p to modulate the down-regulation of PCE [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…In response to S. eriocheiris infection miR-71-3p was upregulated and found to act in a trinity with lncRNA transcript_11191 and PCE [ 40 ]. The proposed mechanism from Ou et al is of lncRNA transcript_11191 acting as a sponge and competitively binding to miR-71-3p to modulate the down-regulation of PCE [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

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Conservation and Targets of miR-71: A Systematic Review and Meta-Analysis

Naidoo

Brennan

Lencastre

2023

ncRNA

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MicroRNAs (miRNAs) perform a pivotal role in the regulation of gene expression across the animal kingdom. As negative regulators of gene expression, miRNAs have been shown to function in the genetic pathways that control many biological processes and have been implicated in roles in human disease. First identified as an aging-associated gene in C. elegans, miR-71, a miRNA, has a demonstrated capability of regulating processes in numerous different invertebrates, including platyhelminths, mollusks, and insects. In these organisms, miR-71 has been shown to affect a diverse range of pathways, including aging, development, and immune response. However, the exact mechanisms by which miR-71 regulates these pathways are not completely understood. In this paper, we review the identified functions of miR-71 across multiple organisms, including identified gene targets, pathways, and the conditions which affect regulatory action. Additionally, the degree of conservation of miR-71 in the evaluated organisms and the conservation of their predicted binding sites in target 3′ UTRs was measured. These studies may provide an insight on the patterns, interactions, and conditions in which miR-71 is able to exert genotypic and phenotypic influence.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Conservation and Targets of miR-71: A Systematic Review and Meta-Analysis

Naidoo

Brennan

Lencastre

2023

ncRNA

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“…There are four action modes in lncRNAs mechanism to interact with a range of DNAs, RNAs, and proteins to modulate the biological functions: (1) acts as molecular signalling inducer that can be used alone or interact with other transcriptional factors or enzymes to mediate the transcription; (2) acts as a molecular decoy which binds to functional proteins or miRNAs, thereby blocking the gene regulation or inhibitory effect of miRNAs on mRNA; (3) acts as a molecular guide to carry the functional proteins and localize on the target DNA area to perform the function; (4) acts as a molecular scaffold in which the same lncRNA binds to multiple transcription factors to regulate gene transcription [8][9][10]. Among these, the interaction between lncRNAs and miRNAs is the predominant action mode found in aquaculture that has been revealed by several studies [11][12][13][14]. However, lncRNAs are less genetically conserved across the species compared to miRNAs, but they can regulate most levels of gene regulations [15].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Regulation in Infectious Diseases and Its Potential as a Biosensor in Future Aquaculture Industry: A Review

SiouNing,

Seong,

Kondo

et al. 2023

Molecules

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An infectious disease is the most apprehensive problem in aquaculture as it can lead to high mortality in aquatic organisms and massive economic loss. Even though significant progress has been accomplished in therapeutic, prevention, and diagnostic using several potential technologies, more robust inventions and breakthroughs should be achieved to control the spread of infectious diseases. MicroRNA (miRNA) is an endogenous small non-coding RNA that post-transcriptionally regulates the protein-coding genes. It involves various biological regulatory mechanisms in organisms such as cell differentiation, proliferation, immune responses, development, apoptosis, and others. Furthermore, an miRNA also acts as a mediator to either regulate host responses or enhance the replication of diseases during infection. Therefore, the emergence of miRNAs could be potential candidates for the establishment of diagnostic tools for numerous infectious diseases. Interestingly, studies have revealed that miRNAs can be used as biomarkers and biosensors to detect diseases, and can also be used to design vaccines to attenuate pathogens. This review provides an overview of miRNA biogenesis and specifically focuses on its regulation during infection in aquatic organisms, especially on the host immune responses and how miRNAs enhance the replication of pathogens in the organism. In addition to that, we explored the potential applications, including diagnostic methods and treatments, that can be employed in the aquaculture industry.

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